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The effect of ambient air pollution on respiratory health of school children: a panel study

BACKGROUND: Adverse respiratory effects of particulate air pollution have been identified by epidemiological studies. We aimed to examine the health effects of ambient particulate air pollution from wood burning on school-age students in Christchurch, New Zealand, and to explore the utility of urine...

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Autores principales: Epton, Michael J, Dawson, Robin D, Brooks, Wendy M, Kingham, Simon, Aberkane, Teresa, Cavanagh, Jo-Anne E, Frampton, Christopher M, Hewitt, Tracey, Cook, Julie M, McLeod, Susan, McCartin, Fiona, Trought, Katherine, Brown, Leslie
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427023/
https://www.ncbi.nlm.nih.gov/pubmed/18479529
http://dx.doi.org/10.1186/1476-069X-7-16
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author Epton, Michael J
Dawson, Robin D
Brooks, Wendy M
Kingham, Simon
Aberkane, Teresa
Cavanagh, Jo-Anne E
Frampton, Christopher M
Hewitt, Tracey
Cook, Julie M
McLeod, Susan
McCartin, Fiona
Trought, Katherine
Brown, Leslie
author_facet Epton, Michael J
Dawson, Robin D
Brooks, Wendy M
Kingham, Simon
Aberkane, Teresa
Cavanagh, Jo-Anne E
Frampton, Christopher M
Hewitt, Tracey
Cook, Julie M
McLeod, Susan
McCartin, Fiona
Trought, Katherine
Brown, Leslie
author_sort Epton, Michael J
collection PubMed
description BACKGROUND: Adverse respiratory effects of particulate air pollution have been identified by epidemiological studies. We aimed to examine the health effects of ambient particulate air pollution from wood burning on school-age students in Christchurch, New Zealand, and to explore the utility of urine and exhaled breath condensate biomarkers of exposure in this population. METHODS: A panel study of 93 male students (26 with asthma) living in the boarding house of a metropolitan school was undertaken in the winter of 2004. Indoor and outdoor pollution data was continuously monitored. Longitudinal assessment of lung function (FEV(1 )and peak flow) and symptoms were undertaken, with event studies of high pollution on biomarkers of exposure (urinary 1-hydroxypyrene) and effect (exhaled breath condensate (EBC) pH and hydrogen peroxide concentration). RESULTS: Peak levels of air pollution were associated with small but statistically significant effects on lung function in the asthmatic students, but not healthy students. No significant effect of pollution could be seen either on airway inflammation and oxidative stress either in healthy students or students with asthma. Minor increases in respiratory symptoms were associated with high pollution exposure. Urinary 1-hydroxypyrene levels were raised in association with pollution events by comparison with low pollution control days. CONCLUSION: There is no significant effect of ambient wood-smoke particulate air pollution on lung function of healthy school-aged students, but a small effect on respiratory symptoms. Asthmatic students show small effects of peak pollution levels on lung function. Urinary 1-hydroxypyrene shows potential as a biomarker of exposure to wood smoke in this population; however measurement of EBC pH and hydrogen peroxide appears not to be useful for assessment of population health effects of air pollution. Some of the data presented in this paper has previously been published in Kingham and co-workers Atmospheric Environment, 2006 Jan; 40: 338–347 (details of pollution exposure), and Cavanagh and co-workers Sci Total Environ. 2007 Mar 1;374(1):51-9 (urine hydroxypyrene data).
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spelling pubmed-24270232008-06-13 The effect of ambient air pollution on respiratory health of school children: a panel study Epton, Michael J Dawson, Robin D Brooks, Wendy M Kingham, Simon Aberkane, Teresa Cavanagh, Jo-Anne E Frampton, Christopher M Hewitt, Tracey Cook, Julie M McLeod, Susan McCartin, Fiona Trought, Katherine Brown, Leslie Environ Health Research BACKGROUND: Adverse respiratory effects of particulate air pollution have been identified by epidemiological studies. We aimed to examine the health effects of ambient particulate air pollution from wood burning on school-age students in Christchurch, New Zealand, and to explore the utility of urine and exhaled breath condensate biomarkers of exposure in this population. METHODS: A panel study of 93 male students (26 with asthma) living in the boarding house of a metropolitan school was undertaken in the winter of 2004. Indoor and outdoor pollution data was continuously monitored. Longitudinal assessment of lung function (FEV(1 )and peak flow) and symptoms were undertaken, with event studies of high pollution on biomarkers of exposure (urinary 1-hydroxypyrene) and effect (exhaled breath condensate (EBC) pH and hydrogen peroxide concentration). RESULTS: Peak levels of air pollution were associated with small but statistically significant effects on lung function in the asthmatic students, but not healthy students. No significant effect of pollution could be seen either on airway inflammation and oxidative stress either in healthy students or students with asthma. Minor increases in respiratory symptoms were associated with high pollution exposure. Urinary 1-hydroxypyrene levels were raised in association with pollution events by comparison with low pollution control days. CONCLUSION: There is no significant effect of ambient wood-smoke particulate air pollution on lung function of healthy school-aged students, but a small effect on respiratory symptoms. Asthmatic students show small effects of peak pollution levels on lung function. Urinary 1-hydroxypyrene shows potential as a biomarker of exposure to wood smoke in this population; however measurement of EBC pH and hydrogen peroxide appears not to be useful for assessment of population health effects of air pollution. Some of the data presented in this paper has previously been published in Kingham and co-workers Atmospheric Environment, 2006 Jan; 40: 338–347 (details of pollution exposure), and Cavanagh and co-workers Sci Total Environ. 2007 Mar 1;374(1):51-9 (urine hydroxypyrene data). BioMed Central 2008-05-14 /pmc/articles/PMC2427023/ /pubmed/18479529 http://dx.doi.org/10.1186/1476-069X-7-16 Text en Copyright © 2008 Epton et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Epton, Michael J
Dawson, Robin D
Brooks, Wendy M
Kingham, Simon
Aberkane, Teresa
Cavanagh, Jo-Anne E
Frampton, Christopher M
Hewitt, Tracey
Cook, Julie M
McLeod, Susan
McCartin, Fiona
Trought, Katherine
Brown, Leslie
The effect of ambient air pollution on respiratory health of school children: a panel study
title The effect of ambient air pollution on respiratory health of school children: a panel study
title_full The effect of ambient air pollution on respiratory health of school children: a panel study
title_fullStr The effect of ambient air pollution on respiratory health of school children: a panel study
title_full_unstemmed The effect of ambient air pollution on respiratory health of school children: a panel study
title_short The effect of ambient air pollution on respiratory health of school children: a panel study
title_sort effect of ambient air pollution on respiratory health of school children: a panel study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427023/
https://www.ncbi.nlm.nih.gov/pubmed/18479529
http://dx.doi.org/10.1186/1476-069X-7-16
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