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Uracil within DNA: an actor of antiviral immunity
Uracil is a natural base of RNA but may appear in DNA through two different pathways including cytosine deamination or misincorporation of deoxyuridine 5'-triphosphate nucleotide (dUTP) during DNA replication and constitutes one of the most frequent DNA lesions. In cellular organisms, such lesi...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427051/ https://www.ncbi.nlm.nih.gov/pubmed/18533995 http://dx.doi.org/10.1186/1742-4690-5-45 |
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author | Sire, Joséphine Quérat, Gilles Esnault, Cécile Priet, Stéphane |
author_facet | Sire, Joséphine Quérat, Gilles Esnault, Cécile Priet, Stéphane |
author_sort | Sire, Joséphine |
collection | PubMed |
description | Uracil is a natural base of RNA but may appear in DNA through two different pathways including cytosine deamination or misincorporation of deoxyuridine 5'-triphosphate nucleotide (dUTP) during DNA replication and constitutes one of the most frequent DNA lesions. In cellular organisms, such lesions are faithfully cleared out through several universal DNA repair mechanisms, thus preventing genome injury. However, several recent studies have brought some pieces of evidence that introduction of uracil bases in viral genomic DNA intermediates during genome replication might be a way of innate immune defence against some viruses. As part of countermeasures, numerous viruses have developed powerful strategies to prevent emergence of uracilated viral genomes and/or to eliminate uracils already incorporated into DNA. This review will present the current knowledge about the cellular and viral countermeasures against uracils in DNA and the implications of these uracils as weapons against viruses. |
format | Text |
id | pubmed-2427051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-24270512008-06-13 Uracil within DNA: an actor of antiviral immunity Sire, Joséphine Quérat, Gilles Esnault, Cécile Priet, Stéphane Retrovirology Review Uracil is a natural base of RNA but may appear in DNA through two different pathways including cytosine deamination or misincorporation of deoxyuridine 5'-triphosphate nucleotide (dUTP) during DNA replication and constitutes one of the most frequent DNA lesions. In cellular organisms, such lesions are faithfully cleared out through several universal DNA repair mechanisms, thus preventing genome injury. However, several recent studies have brought some pieces of evidence that introduction of uracil bases in viral genomic DNA intermediates during genome replication might be a way of innate immune defence against some viruses. As part of countermeasures, numerous viruses have developed powerful strategies to prevent emergence of uracilated viral genomes and/or to eliminate uracils already incorporated into DNA. This review will present the current knowledge about the cellular and viral countermeasures against uracils in DNA and the implications of these uracils as weapons against viruses. BioMed Central 2008-06-05 /pmc/articles/PMC2427051/ /pubmed/18533995 http://dx.doi.org/10.1186/1742-4690-5-45 Text en Copyright © 2008 Sire et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Sire, Joséphine Quérat, Gilles Esnault, Cécile Priet, Stéphane Uracil within DNA: an actor of antiviral immunity |
title | Uracil within DNA: an actor of antiviral immunity |
title_full | Uracil within DNA: an actor of antiviral immunity |
title_fullStr | Uracil within DNA: an actor of antiviral immunity |
title_full_unstemmed | Uracil within DNA: an actor of antiviral immunity |
title_short | Uracil within DNA: an actor of antiviral immunity |
title_sort | uracil within dna: an actor of antiviral immunity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427051/ https://www.ncbi.nlm.nih.gov/pubmed/18533995 http://dx.doi.org/10.1186/1742-4690-5-45 |
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