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Uracil within DNA: an actor of antiviral immunity

Uracil is a natural base of RNA but may appear in DNA through two different pathways including cytosine deamination or misincorporation of deoxyuridine 5'-triphosphate nucleotide (dUTP) during DNA replication and constitutes one of the most frequent DNA lesions. In cellular organisms, such lesi...

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Autores principales: Sire, Joséphine, Quérat, Gilles, Esnault, Cécile, Priet, Stéphane
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427051/
https://www.ncbi.nlm.nih.gov/pubmed/18533995
http://dx.doi.org/10.1186/1742-4690-5-45
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author Sire, Joséphine
Quérat, Gilles
Esnault, Cécile
Priet, Stéphane
author_facet Sire, Joséphine
Quérat, Gilles
Esnault, Cécile
Priet, Stéphane
author_sort Sire, Joséphine
collection PubMed
description Uracil is a natural base of RNA but may appear in DNA through two different pathways including cytosine deamination or misincorporation of deoxyuridine 5'-triphosphate nucleotide (dUTP) during DNA replication and constitutes one of the most frequent DNA lesions. In cellular organisms, such lesions are faithfully cleared out through several universal DNA repair mechanisms, thus preventing genome injury. However, several recent studies have brought some pieces of evidence that introduction of uracil bases in viral genomic DNA intermediates during genome replication might be a way of innate immune defence against some viruses. As part of countermeasures, numerous viruses have developed powerful strategies to prevent emergence of uracilated viral genomes and/or to eliminate uracils already incorporated into DNA. This review will present the current knowledge about the cellular and viral countermeasures against uracils in DNA and the implications of these uracils as weapons against viruses.
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spelling pubmed-24270512008-06-13 Uracil within DNA: an actor of antiviral immunity Sire, Joséphine Quérat, Gilles Esnault, Cécile Priet, Stéphane Retrovirology Review Uracil is a natural base of RNA but may appear in DNA through two different pathways including cytosine deamination or misincorporation of deoxyuridine 5'-triphosphate nucleotide (dUTP) during DNA replication and constitutes one of the most frequent DNA lesions. In cellular organisms, such lesions are faithfully cleared out through several universal DNA repair mechanisms, thus preventing genome injury. However, several recent studies have brought some pieces of evidence that introduction of uracil bases in viral genomic DNA intermediates during genome replication might be a way of innate immune defence against some viruses. As part of countermeasures, numerous viruses have developed powerful strategies to prevent emergence of uracilated viral genomes and/or to eliminate uracils already incorporated into DNA. This review will present the current knowledge about the cellular and viral countermeasures against uracils in DNA and the implications of these uracils as weapons against viruses. BioMed Central 2008-06-05 /pmc/articles/PMC2427051/ /pubmed/18533995 http://dx.doi.org/10.1186/1742-4690-5-45 Text en Copyright © 2008 Sire et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Sire, Joséphine
Quérat, Gilles
Esnault, Cécile
Priet, Stéphane
Uracil within DNA: an actor of antiviral immunity
title Uracil within DNA: an actor of antiviral immunity
title_full Uracil within DNA: an actor of antiviral immunity
title_fullStr Uracil within DNA: an actor of antiviral immunity
title_full_unstemmed Uracil within DNA: an actor of antiviral immunity
title_short Uracil within DNA: an actor of antiviral immunity
title_sort uracil within dna: an actor of antiviral immunity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427051/
https://www.ncbi.nlm.nih.gov/pubmed/18533995
http://dx.doi.org/10.1186/1742-4690-5-45
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