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Hydrogen Peroxide Promotes Aβ Production through JNK-dependent Activation of γ-Secretase

Accumulation of senile plaques composed of amyloid β-peptide (Aβ) is a pathological hallmark of Alzheimer disease (AD), and Aβ is generated through the sequential cleavage of amyloid precursor protein (APP) by β- and γ-secretase. Although oxidative stress has been implicated in the AD pathogenesis b...

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Detalles Bibliográficos
Autores principales:	Shen, Chengyong, Chen, Yongfeng, Liu, Huaqing, Zhang, Kejing, Zhang, Ting, Lin, Anning, Jing, Naihe
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2008
Materias:	Mechanisms of Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427353/ https://www.ncbi.nlm.nih.gov/pubmed/18436531 http://dx.doi.org/10.1074/jbc.M800013200

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