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Leishmania Trypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities

The bifunctional trypanothione synthetase-amidase catalyzes biosynthesis and hydrolysis of the glutathione-spermidine adduct trypanothione, the principal intracellular thiol-redox metabolite in parasitic trypanosomatids. These parasites are unique with regard to their reliance on trypanothione to de...

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Detalles Bibliográficos
Autores principales:	Fyfe, Paul K., Oza, Sandra L., Fairlamb, Alan H., Hunter, William N.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2008
Materias:	Enzyme Catalysis and Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427367/ https://www.ncbi.nlm.nih.gov/pubmed/18420578 http://dx.doi.org/10.1074/jbc.M801850200

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