Role of X11 and ubiquilin as In Vivo Regulators of the Amyloid Precursor Protein in Drosophila

The Amyloid Precursor Protein (APP) undergoes sequential proteolytic cleavages through the action of β- and γ-secretase, which result in the generation of toxic β-amyloid (Aβ) peptides and a C-terminal fragment consisting of the intracellular domain of APP (AICD). Mutations leading to increased APP...

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Detalles Bibliográficos
Autores principales: Gross, Garrett G., Feldman, R. M. Renny, Ganguly, Atish, Wang, Jinhui, Yu, Hong, Guo, Ming
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2429963/
https://www.ncbi.nlm.nih.gov/pubmed/18575606
http://dx.doi.org/10.1371/journal.pone.0002495

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