A Francisella tularensis Schu S4 Purine Auxotroph Is Highly Attenuated in Mice but Offers Limited Protection against Homologous Intranasal Challenge

BACKGROUND: Francisella tularensis is a Gram-negative coccobacillus that causes the febrile illness tularemia. Subspecies that are pathogenic for humans include those comprising the type A (subspecies tularensis) or type B (subspecies holarctica) biovars. An attenuated live vaccine strain (LVS) deve...

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Detalles Bibliográficos
Autores principales: Pechous, Roger D., McCarthy, Travis R., Mohapatra, Nrusingh P., Soni, Shilpa, Penoske, Renee M., Salzman, Nita H., Frank, Dara W., Gunn, John S., Zahrt, Thomas C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2429968/
https://www.ncbi.nlm.nih.gov/pubmed/18575611
http://dx.doi.org/10.1371/journal.pone.0002487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2429968/
https://www.ncbi.nlm.nih.gov/pubmed/18575611
http://dx.doi.org/10.1371/journal.pone.0002487

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