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A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer

Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. PPARγ and its ligands appear to serve diverse biological functions. In addition to the well-studied effects of PPARγ on metabolism and cellular differenti...

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Detalles Bibliográficos
Autores principales: Yang, Xiao Yi, Wang, Li Hua, Farrar, William L.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430015/
https://www.ncbi.nlm.nih.gov/pubmed/18566687
http://dx.doi.org/10.1155/2008/961753
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author Yang, Xiao Yi
Wang, Li Hua
Farrar, William L.
author_facet Yang, Xiao Yi
Wang, Li Hua
Farrar, William L.
author_sort Yang, Xiao Yi
collection PubMed
description Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. PPARγ and its ligands appear to serve diverse biological functions. In addition to the well-studied effects of PPARγ on metabolism and cellular differentiation, abundant evidence suggests that PPARγ is an important regulator of the immune system and cancers. Since cytokines are not only key modulators of inflammation with pro- and anti-inflammatory functions but they also can either stimulate or inhibit tumor growth and progression, this review summarizes the role for PPARγ in the regulation of cytokine production and cytokine-mediated signal transduction pathways in immune cells and cancer.
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spelling pubmed-24300152008-06-19 A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer Yang, Xiao Yi Wang, Li Hua Farrar, William L. PPAR Res Review Article Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. PPARγ and its ligands appear to serve diverse biological functions. In addition to the well-studied effects of PPARγ on metabolism and cellular differentiation, abundant evidence suggests that PPARγ is an important regulator of the immune system and cancers. Since cytokines are not only key modulators of inflammation with pro- and anti-inflammatory functions but they also can either stimulate or inhibit tumor growth and progression, this review summarizes the role for PPARγ in the regulation of cytokine production and cytokine-mediated signal transduction pathways in immune cells and cancer. Hindawi Publishing Corporation 2008 2008-06-12 /pmc/articles/PMC2430015/ /pubmed/18566687 http://dx.doi.org/10.1155/2008/961753 Text en Copyright © 2008 Xiao Yi Yang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yang, Xiao Yi
Wang, Li Hua
Farrar, William L.
A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer
title A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer
title_full A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer
title_fullStr A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer
title_full_unstemmed A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer
title_short A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer
title_sort role for pparγ in the regulation of cytokines in immune cells and cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430015/
https://www.ncbi.nlm.nih.gov/pubmed/18566687
http://dx.doi.org/10.1155/2008/961753
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