Cargando…
Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes
BACKGROUND: Prior studies of prenatal exposure to tetrachloroethylene (PCE) have shown mixed results regarding its effect on birth weight and gestational age. OBJECTIVES: In this retrospective cohort study we examined whether PCE contamination of public drinking-water supplies in Massachusetts influ...
Autores principales: | , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
National Institute of Environmental Health Sciences
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430239/ https://www.ncbi.nlm.nih.gov/pubmed/18560539 http://dx.doi.org/10.1289/ehp.10414 |
_version_ | 1782156377929547776 |
---|---|
author | Aschengrau, Ann Weinberg, Janice Rogers, Sarah Gallagher, Lisa Winter, Michael Vieira, Veronica Webster, Thomas Ozonoff, David |
author_facet | Aschengrau, Ann Weinberg, Janice Rogers, Sarah Gallagher, Lisa Winter, Michael Vieira, Veronica Webster, Thomas Ozonoff, David |
author_sort | Aschengrau, Ann |
collection | PubMed |
description | BACKGROUND: Prior studies of prenatal exposure to tetrachloroethylene (PCE) have shown mixed results regarding its effect on birth weight and gestational age. OBJECTIVES: In this retrospective cohort study we examined whether PCE contamination of public drinking-water supplies in Massachusetts influenced the birth weight and gestational duration of children whose mothers were exposed before the child’s delivery. METHODS: The study included 1,353 children whose mothers were exposed to PCE-contaminated drinking water and a comparable group of 772 children of unexposed mothers. Birth records were used to identify subjects and provide information on the outcomes. Mothers completed a questionnaire to gather information on residential histories and confounding variables. PCE exposure was estimated using EPANET water distribution system modeling software that incorporated a fate and transport model. RESULTS: We found no meaningful associations between PCE exposure and birth weight or gestational duration. Compared with children whose mothers were unexposed during the year of the last menstrual period (LMP), adjusted mean differences in birth weight were 20.9, 6.2, 30.1, and 15.2 g for children whose mothers’ average monthly exposure during the LMP year ranged from the lowest to highest quartile. Similarly, compared with unexposed children, adjusted mean differences in gestational age were −0.2, 0.1, −0.1, and −0.2 weeks for children whose mothers’ average monthly exposure ranged from the lowest to highest quartile. Similar results were observed for two other measures of prenatal exposure. CONCLUSIONS: These results suggest that prenatal PCE exposure does not have an adverse effect on these birth outcomes at the exposure levels experienced by this population. |
format | Text |
id | pubmed-2430239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-24302392008-06-17 Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes Aschengrau, Ann Weinberg, Janice Rogers, Sarah Gallagher, Lisa Winter, Michael Vieira, Veronica Webster, Thomas Ozonoff, David Environ Health Perspect Research BACKGROUND: Prior studies of prenatal exposure to tetrachloroethylene (PCE) have shown mixed results regarding its effect on birth weight and gestational age. OBJECTIVES: In this retrospective cohort study we examined whether PCE contamination of public drinking-water supplies in Massachusetts influenced the birth weight and gestational duration of children whose mothers were exposed before the child’s delivery. METHODS: The study included 1,353 children whose mothers were exposed to PCE-contaminated drinking water and a comparable group of 772 children of unexposed mothers. Birth records were used to identify subjects and provide information on the outcomes. Mothers completed a questionnaire to gather information on residential histories and confounding variables. PCE exposure was estimated using EPANET water distribution system modeling software that incorporated a fate and transport model. RESULTS: We found no meaningful associations between PCE exposure and birth weight or gestational duration. Compared with children whose mothers were unexposed during the year of the last menstrual period (LMP), adjusted mean differences in birth weight were 20.9, 6.2, 30.1, and 15.2 g for children whose mothers’ average monthly exposure during the LMP year ranged from the lowest to highest quartile. Similarly, compared with unexposed children, adjusted mean differences in gestational age were −0.2, 0.1, −0.1, and −0.2 weeks for children whose mothers’ average monthly exposure ranged from the lowest to highest quartile. Similar results were observed for two other measures of prenatal exposure. CONCLUSIONS: These results suggest that prenatal PCE exposure does not have an adverse effect on these birth outcomes at the exposure levels experienced by this population. National Institute of Environmental Health Sciences 2008-06 2008-02-06 /pmc/articles/PMC2430239/ /pubmed/18560539 http://dx.doi.org/10.1289/ehp.10414 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Aschengrau, Ann Weinberg, Janice Rogers, Sarah Gallagher, Lisa Winter, Michael Vieira, Veronica Webster, Thomas Ozonoff, David Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes |
title | Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes |
title_full | Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes |
title_fullStr | Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes |
title_full_unstemmed | Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes |
title_short | Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes |
title_sort | prenatal exposure to tetrachloroethylene-contaminated drinking water and the risk of adverse birth outcomes |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430239/ https://www.ncbi.nlm.nih.gov/pubmed/18560539 http://dx.doi.org/10.1289/ehp.10414 |
work_keys_str_mv | AT aschengrauann prenatalexposuretotetrachloroethylenecontaminateddrinkingwaterandtheriskofadversebirthoutcomes AT weinbergjanice prenatalexposuretotetrachloroethylenecontaminateddrinkingwaterandtheriskofadversebirthoutcomes AT rogerssarah prenatalexposuretotetrachloroethylenecontaminateddrinkingwaterandtheriskofadversebirthoutcomes AT gallagherlisa prenatalexposuretotetrachloroethylenecontaminateddrinkingwaterandtheriskofadversebirthoutcomes AT wintermichael prenatalexposuretotetrachloroethylenecontaminateddrinkingwaterandtheriskofadversebirthoutcomes AT vieiraveronica prenatalexposuretotetrachloroethylenecontaminateddrinkingwaterandtheriskofadversebirthoutcomes AT websterthomas prenatalexposuretotetrachloroethylenecontaminateddrinkingwaterandtheriskofadversebirthoutcomes AT ozonoffdavid prenatalexposuretotetrachloroethylenecontaminateddrinkingwaterandtheriskofadversebirthoutcomes |