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Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes

BACKGROUND: Prior studies of prenatal exposure to tetrachloroethylene (PCE) have shown mixed results regarding its effect on birth weight and gestational age. OBJECTIVES: In this retrospective cohort study we examined whether PCE contamination of public drinking-water supplies in Massachusetts influ...

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Autores principales: Aschengrau, Ann, Weinberg, Janice, Rogers, Sarah, Gallagher, Lisa, Winter, Michael, Vieira, Veronica, Webster, Thomas, Ozonoff, David
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430239/
https://www.ncbi.nlm.nih.gov/pubmed/18560539
http://dx.doi.org/10.1289/ehp.10414
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author Aschengrau, Ann
Weinberg, Janice
Rogers, Sarah
Gallagher, Lisa
Winter, Michael
Vieira, Veronica
Webster, Thomas
Ozonoff, David
author_facet Aschengrau, Ann
Weinberg, Janice
Rogers, Sarah
Gallagher, Lisa
Winter, Michael
Vieira, Veronica
Webster, Thomas
Ozonoff, David
author_sort Aschengrau, Ann
collection PubMed
description BACKGROUND: Prior studies of prenatal exposure to tetrachloroethylene (PCE) have shown mixed results regarding its effect on birth weight and gestational age. OBJECTIVES: In this retrospective cohort study we examined whether PCE contamination of public drinking-water supplies in Massachusetts influenced the birth weight and gestational duration of children whose mothers were exposed before the child’s delivery. METHODS: The study included 1,353 children whose mothers were exposed to PCE-contaminated drinking water and a comparable group of 772 children of unexposed mothers. Birth records were used to identify subjects and provide information on the outcomes. Mothers completed a questionnaire to gather information on residential histories and confounding variables. PCE exposure was estimated using EPANET water distribution system modeling software that incorporated a fate and transport model. RESULTS: We found no meaningful associations between PCE exposure and birth weight or gestational duration. Compared with children whose mothers were unexposed during the year of the last menstrual period (LMP), adjusted mean differences in birth weight were 20.9, 6.2, 30.1, and 15.2 g for children whose mothers’ average monthly exposure during the LMP year ranged from the lowest to highest quartile. Similarly, compared with unexposed children, adjusted mean differences in gestational age were −0.2, 0.1, −0.1, and −0.2 weeks for children whose mothers’ average monthly exposure ranged from the lowest to highest quartile. Similar results were observed for two other measures of prenatal exposure. CONCLUSIONS: These results suggest that prenatal PCE exposure does not have an adverse effect on these birth outcomes at the exposure levels experienced by this population.
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spelling pubmed-24302392008-06-17 Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes Aschengrau, Ann Weinberg, Janice Rogers, Sarah Gallagher, Lisa Winter, Michael Vieira, Veronica Webster, Thomas Ozonoff, David Environ Health Perspect Research BACKGROUND: Prior studies of prenatal exposure to tetrachloroethylene (PCE) have shown mixed results regarding its effect on birth weight and gestational age. OBJECTIVES: In this retrospective cohort study we examined whether PCE contamination of public drinking-water supplies in Massachusetts influenced the birth weight and gestational duration of children whose mothers were exposed before the child’s delivery. METHODS: The study included 1,353 children whose mothers were exposed to PCE-contaminated drinking water and a comparable group of 772 children of unexposed mothers. Birth records were used to identify subjects and provide information on the outcomes. Mothers completed a questionnaire to gather information on residential histories and confounding variables. PCE exposure was estimated using EPANET water distribution system modeling software that incorporated a fate and transport model. RESULTS: We found no meaningful associations between PCE exposure and birth weight or gestational duration. Compared with children whose mothers were unexposed during the year of the last menstrual period (LMP), adjusted mean differences in birth weight were 20.9, 6.2, 30.1, and 15.2 g for children whose mothers’ average monthly exposure during the LMP year ranged from the lowest to highest quartile. Similarly, compared with unexposed children, adjusted mean differences in gestational age were −0.2, 0.1, −0.1, and −0.2 weeks for children whose mothers’ average monthly exposure ranged from the lowest to highest quartile. Similar results were observed for two other measures of prenatal exposure. CONCLUSIONS: These results suggest that prenatal PCE exposure does not have an adverse effect on these birth outcomes at the exposure levels experienced by this population. National Institute of Environmental Health Sciences 2008-06 2008-02-06 /pmc/articles/PMC2430239/ /pubmed/18560539 http://dx.doi.org/10.1289/ehp.10414 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Aschengrau, Ann
Weinberg, Janice
Rogers, Sarah
Gallagher, Lisa
Winter, Michael
Vieira, Veronica
Webster, Thomas
Ozonoff, David
Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes
title Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes
title_full Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes
title_fullStr Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes
title_full_unstemmed Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes
title_short Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes
title_sort prenatal exposure to tetrachloroethylene-contaminated drinking water and the risk of adverse birth outcomes
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430239/
https://www.ncbi.nlm.nih.gov/pubmed/18560539
http://dx.doi.org/10.1289/ehp.10414
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