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TRPM8 mechanism of autonomic nerve response to cold in respiratory airway

Breathing cold air without proper temperature exchange can induce strong respiratory autonomic responses including cough, airway constriction and mucosal secretion, and can exacerbate existing asthma conditions and even directly trigger an asthma attack. Vagal afferent fiber is thought to be involve...

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Autores principales: Xing, Hong, Ling, Jennifer X, Chen, Meng, Johnson, Richard D, Tominaga, Makoto, Wang, Cong-Yi, Gu, Jianguo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430548/
https://www.ncbi.nlm.nih.gov/pubmed/18534015
http://dx.doi.org/10.1186/1744-8069-4-22
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author Xing, Hong
Ling, Jennifer X
Chen, Meng
Johnson, Richard D
Tominaga, Makoto
Wang, Cong-Yi
Gu, Jianguo
author_facet Xing, Hong
Ling, Jennifer X
Chen, Meng
Johnson, Richard D
Tominaga, Makoto
Wang, Cong-Yi
Gu, Jianguo
author_sort Xing, Hong
collection PubMed
description Breathing cold air without proper temperature exchange can induce strong respiratory autonomic responses including cough, airway constriction and mucosal secretion, and can exacerbate existing asthma conditions and even directly trigger an asthma attack. Vagal afferent fiber is thought to be involved in the cold-induced respiratory responses through autonomic nerve reflex. However, molecular mechanisms by which vagal afferent fibers are excited by cold remain unknown. Using retrograde labeling, immunostaining, calcium imaging, and electrophysiological recordings, here we show that a subpopulation of airway vagal afferent nerves express TRPM8 receptors and that activation of TRPM8 receptors by cold excites these airway autonomic nerves. Thus activation of TRPM8 receptors may provoke autonomic nerve reflex to increase airway resistance. This putative autonomic response may be associated with cold-induced exacerbation of asthma and other pulmonary disorders, making TRPM8 receptors a possible target for prevention of cold-associated respiratory disorders.
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spelling pubmed-24305482008-06-18 TRPM8 mechanism of autonomic nerve response to cold in respiratory airway Xing, Hong Ling, Jennifer X Chen, Meng Johnson, Richard D Tominaga, Makoto Wang, Cong-Yi Gu, Jianguo Mol Pain Research Breathing cold air without proper temperature exchange can induce strong respiratory autonomic responses including cough, airway constriction and mucosal secretion, and can exacerbate existing asthma conditions and even directly trigger an asthma attack. Vagal afferent fiber is thought to be involved in the cold-induced respiratory responses through autonomic nerve reflex. However, molecular mechanisms by which vagal afferent fibers are excited by cold remain unknown. Using retrograde labeling, immunostaining, calcium imaging, and electrophysiological recordings, here we show that a subpopulation of airway vagal afferent nerves express TRPM8 receptors and that activation of TRPM8 receptors by cold excites these airway autonomic nerves. Thus activation of TRPM8 receptors may provoke autonomic nerve reflex to increase airway resistance. This putative autonomic response may be associated with cold-induced exacerbation of asthma and other pulmonary disorders, making TRPM8 receptors a possible target for prevention of cold-associated respiratory disorders. BioMed Central 2008-06-05 /pmc/articles/PMC2430548/ /pubmed/18534015 http://dx.doi.org/10.1186/1744-8069-4-22 Text en Copyright © 2008 Xing et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Xing, Hong
Ling, Jennifer X
Chen, Meng
Johnson, Richard D
Tominaga, Makoto
Wang, Cong-Yi
Gu, Jianguo
TRPM8 mechanism of autonomic nerve response to cold in respiratory airway
title TRPM8 mechanism of autonomic nerve response to cold in respiratory airway
title_full TRPM8 mechanism of autonomic nerve response to cold in respiratory airway
title_fullStr TRPM8 mechanism of autonomic nerve response to cold in respiratory airway
title_full_unstemmed TRPM8 mechanism of autonomic nerve response to cold in respiratory airway
title_short TRPM8 mechanism of autonomic nerve response to cold in respiratory airway
title_sort trpm8 mechanism of autonomic nerve response to cold in respiratory airway
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430548/
https://www.ncbi.nlm.nih.gov/pubmed/18534015
http://dx.doi.org/10.1186/1744-8069-4-22
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