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Transformation of MCF-10A cells by random mutagenesis with frameshift mutagen ICR191: A model for identifying candidate breast-tumor suppressors

BACKGROUND: Widely accepted somatic mutation theory of carcinogenesis states that mutations in oncogenes and tumor suppressor genes in genomes of somatic cells is the cause of neoplastic transformation. Identifying frequent mutations in cancer cells suggests the involvement of mutant genes in carcin...

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Detalles Bibliográficos
Autores principales:	Zientek-Targosz, Helena, Kunnev, Dimiter, Hawthorn, Lesleyann, Venkov, Mikhail, Matsui, Sei-Ichi, Cheney, Richard T, Ionov, Yuri
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430587/ https://www.ncbi.nlm.nih.gov/pubmed/18534021 http://dx.doi.org/10.1186/1476-4598-7-51

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