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Henoch-Schönlein purpura with intracerebral haemorrhage in an adult patient: a case report

INTRODUCTION: Henoch-Schönlein purpura is a small vessel vasculitis that affects mainly the skin, joints, gastrointestinal tract and kidneys. The central nervous system is also occasionally affected, although the majority of patients experience only mild symptoms such as headaches and behavioural ch...

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Autores principales: Karamadoukis, Lazarus, Ludeman, Linmarie, Williams, Anthony J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430708/
https://www.ncbi.nlm.nih.gov/pubmed/18547440
http://dx.doi.org/10.1186/1752-1947-2-200
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author Karamadoukis, Lazarus
Ludeman, Linmarie
Williams, Anthony J
author_facet Karamadoukis, Lazarus
Ludeman, Linmarie
Williams, Anthony J
author_sort Karamadoukis, Lazarus
collection PubMed
description INTRODUCTION: Henoch-Schönlein purpura is a small vessel vasculitis that affects mainly the skin, joints, gastrointestinal tract and kidneys. The central nervous system is also occasionally affected, although the majority of patients experience only mild symptoms such as headaches and behavioural changes. Intracerebral haemorrhage is a rare complication of Henoch-Schönlein purpura that so far has mainly been described in children and young adolescence. CASE PRESENTATION: We describe a 42-year-old man with Henoch-Schönlein purpura who developed an acute intracerebral haemorrhage that coincided with a reactivation of his vasculitis and the development of renal failure following discontinuation of steroids. In this patient, both the Henoch-Schönlein purpura and his neurological symptoms were successfully treated with intravenous cyclophosphamide and methylprednisolone, followed by a short course of oral cyclophosphamide and long-term oral prednisolone. His renal function also recovered sufficiently not to require renal replacement therapy. CONCLUSION: The management of Henoch-Schönlein nephritis remains unclear, especially in the presence of severe complications such as intracerebral haemorrhage. We describe a successful outcome in such a patient.
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spelling pubmed-24307082008-06-19 Henoch-Schönlein purpura with intracerebral haemorrhage in an adult patient: a case report Karamadoukis, Lazarus Ludeman, Linmarie Williams, Anthony J J Med Case Reports Case Report INTRODUCTION: Henoch-Schönlein purpura is a small vessel vasculitis that affects mainly the skin, joints, gastrointestinal tract and kidneys. The central nervous system is also occasionally affected, although the majority of patients experience only mild symptoms such as headaches and behavioural changes. Intracerebral haemorrhage is a rare complication of Henoch-Schönlein purpura that so far has mainly been described in children and young adolescence. CASE PRESENTATION: We describe a 42-year-old man with Henoch-Schönlein purpura who developed an acute intracerebral haemorrhage that coincided with a reactivation of his vasculitis and the development of renal failure following discontinuation of steroids. In this patient, both the Henoch-Schönlein purpura and his neurological symptoms were successfully treated with intravenous cyclophosphamide and methylprednisolone, followed by a short course of oral cyclophosphamide and long-term oral prednisolone. His renal function also recovered sufficiently not to require renal replacement therapy. CONCLUSION: The management of Henoch-Schönlein nephritis remains unclear, especially in the presence of severe complications such as intracerebral haemorrhage. We describe a successful outcome in such a patient. BioMed Central 2008-06-12 /pmc/articles/PMC2430708/ /pubmed/18547440 http://dx.doi.org/10.1186/1752-1947-2-200 Text en Copyright © 2008 Karamadoukis et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Karamadoukis, Lazarus
Ludeman, Linmarie
Williams, Anthony J
Henoch-Schönlein purpura with intracerebral haemorrhage in an adult patient: a case report
title Henoch-Schönlein purpura with intracerebral haemorrhage in an adult patient: a case report
title_full Henoch-Schönlein purpura with intracerebral haemorrhage in an adult patient: a case report
title_fullStr Henoch-Schönlein purpura with intracerebral haemorrhage in an adult patient: a case report
title_full_unstemmed Henoch-Schönlein purpura with intracerebral haemorrhage in an adult patient: a case report
title_short Henoch-Schönlein purpura with intracerebral haemorrhage in an adult patient: a case report
title_sort henoch-schönlein purpura with intracerebral haemorrhage in an adult patient: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430708/
https://www.ncbi.nlm.nih.gov/pubmed/18547440
http://dx.doi.org/10.1186/1752-1947-2-200
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