Decrease in tobacco consumption after treatment with topiramate and aripiprazole: a case report

INTRODUCTION: A large part of research into drug addiction focuses on mesolimbic dopamine circuitry; however, both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and/or kainate and dopamine D2 receptors can play a role in maintaining the established addiction. CASE PRESENTATION: We report...

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Detalles Bibliográficos
Autores principales: Arbaizar, Beatriz, Gómez-Acebo, Inés, Llorca, Javier
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2432067/
https://www.ncbi.nlm.nih.gov/pubmed/18547425
http://dx.doi.org/10.1186/1752-1947-2-198
Descripción
Sumario:INTRODUCTION: A large part of research into drug addiction focuses on mesolimbic dopamine circuitry; however, both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and/or kainate and dopamine D2 receptors can play a role in maintaining the established addiction. CASE PRESENTATION: We report the case of a 34-year-old man who compulsively smoked 80 to 100 cigarettes each day. After receiving treatment with topiramate and aripiprazole, his tobacco consumption was dramatically reduced. CONCLUSION: Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and/or kainate blocking agents and a dopamine D2 receptor partial agonist may be novel instruments for nicotine abuse disorders.

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