The Efficacy of Generating Three Independent Anti-HIV-1 siRNAs from a Single U6 RNA Pol III-Expressed Long Hairpin RNA

RNA Interference (RNAi) effectors have been used to inhibit rogue RNAs in mammalian cells. However, rapidly evolving sequences such as the human immunodeficiency virus type 1 (HIV-1) require multiple targeting approaches to prevent the emergence of escape variants. Expressed long hairpin RNAs (lhRNA...

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Detalles Bibliográficos
Autores principales: Saayman, Sheena, Barichievy, Samantha, Capovilla, Alexio, Morris, Kevin V., Arbuthnot, Patrick, Weinberg, Marc S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2434202/
https://www.ncbi.nlm.nih.gov/pubmed/18596982
http://dx.doi.org/10.1371/journal.pone.0002602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2434202/
https://www.ncbi.nlm.nih.gov/pubmed/18596982
http://dx.doi.org/10.1371/journal.pone.0002602

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