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Circumferential 2D-strain imaging for the prediction of long term response to cardiac resynchronization therapy

BACKGROUND: Cardiac Resynchronization Therapy (CRT) leads to hemodynamic and clinical improvement in heart failure patients. The established methods to evaluate myocardial asynchrony analyze longitudinal and radial myocardial function. This study evaluates the new method of circumferential 2D-strain...

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Autores principales: Knebel, Fabian, Schattke, Sebastian, Bondke, Hansjürgen, Eddicks, Stephan, Grohmann, Andrea, Baumann, Gert, Borges, Adrian C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435102/
https://www.ncbi.nlm.nih.gov/pubmed/18538011
http://dx.doi.org/10.1186/1476-7120-6-28
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author Knebel, Fabian
Schattke, Sebastian
Bondke, Hansjürgen
Eddicks, Stephan
Grohmann, Andrea
Baumann, Gert
Borges, Adrian C
author_facet Knebel, Fabian
Schattke, Sebastian
Bondke, Hansjürgen
Eddicks, Stephan
Grohmann, Andrea
Baumann, Gert
Borges, Adrian C
author_sort Knebel, Fabian
collection PubMed
description BACKGROUND: Cardiac Resynchronization Therapy (CRT) leads to hemodynamic and clinical improvement in heart failure patients. The established methods to evaluate myocardial asynchrony analyze longitudinal and radial myocardial function. This study evaluates the new method of circumferential 2D-strain imaging in the prediction of the long-term response to CRT. METHODS AND RESULTS: 38 heart failure patients (NYHA II-III, QRS > 120 ms, LVEF < 0.35) received CRT and echocardiographic evaluation with a mean follow-up of 9.4 months. 18 (47.4%) of the patients were hemodynamic responders to long-term CRT. In the responder group, the maximum delay in the circumferential 2D-strain in the basal segments decreased (246 ± 94 to 123 ± 92 ms, p < 0.001). In the non-responder group there was no significant change (pre CRT: 195 ± 86, post CRT 135 ± 136 ms, p = 0.84). This was paralleled by a reduction of the maximum delay in the radial and longitudinal 2D strain in the basal segments. In ROC analysis, the baseline delay of circumferential 2D strain (AUC 0.66 (± 0.14)) does not predict a long-term response to CRT (p = 0.37). CONCLUSION: There is a significant decrease in the circumferential 2D-strain derived delays after CRT, indicating that resynchronization induces improvement in all three dimensions of myocardial contraction. However, the resulting predictive values of 2D strain delays are not superior to longitudinal and radial 2D-strain or TDI delays.
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spelling pubmed-24351022008-06-21 Circumferential 2D-strain imaging for the prediction of long term response to cardiac resynchronization therapy Knebel, Fabian Schattke, Sebastian Bondke, Hansjürgen Eddicks, Stephan Grohmann, Andrea Baumann, Gert Borges, Adrian C Cardiovasc Ultrasound Research BACKGROUND: Cardiac Resynchronization Therapy (CRT) leads to hemodynamic and clinical improvement in heart failure patients. The established methods to evaluate myocardial asynchrony analyze longitudinal and radial myocardial function. This study evaluates the new method of circumferential 2D-strain imaging in the prediction of the long-term response to CRT. METHODS AND RESULTS: 38 heart failure patients (NYHA II-III, QRS > 120 ms, LVEF < 0.35) received CRT and echocardiographic evaluation with a mean follow-up of 9.4 months. 18 (47.4%) of the patients were hemodynamic responders to long-term CRT. In the responder group, the maximum delay in the circumferential 2D-strain in the basal segments decreased (246 ± 94 to 123 ± 92 ms, p < 0.001). In the non-responder group there was no significant change (pre CRT: 195 ± 86, post CRT 135 ± 136 ms, p = 0.84). This was paralleled by a reduction of the maximum delay in the radial and longitudinal 2D strain in the basal segments. In ROC analysis, the baseline delay of circumferential 2D strain (AUC 0.66 (± 0.14)) does not predict a long-term response to CRT (p = 0.37). CONCLUSION: There is a significant decrease in the circumferential 2D-strain derived delays after CRT, indicating that resynchronization induces improvement in all three dimensions of myocardial contraction. However, the resulting predictive values of 2D strain delays are not superior to longitudinal and radial 2D-strain or TDI delays. BioMed Central 2008-06-06 /pmc/articles/PMC2435102/ /pubmed/18538011 http://dx.doi.org/10.1186/1476-7120-6-28 Text en Copyright © 2008 Knebel et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Knebel, Fabian
Schattke, Sebastian
Bondke, Hansjürgen
Eddicks, Stephan
Grohmann, Andrea
Baumann, Gert
Borges, Adrian C
Circumferential 2D-strain imaging for the prediction of long term response to cardiac resynchronization therapy
title Circumferential 2D-strain imaging for the prediction of long term response to cardiac resynchronization therapy
title_full Circumferential 2D-strain imaging for the prediction of long term response to cardiac resynchronization therapy
title_fullStr Circumferential 2D-strain imaging for the prediction of long term response to cardiac resynchronization therapy
title_full_unstemmed Circumferential 2D-strain imaging for the prediction of long term response to cardiac resynchronization therapy
title_short Circumferential 2D-strain imaging for the prediction of long term response to cardiac resynchronization therapy
title_sort circumferential 2d-strain imaging for the prediction of long term response to cardiac resynchronization therapy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435102/
https://www.ncbi.nlm.nih.gov/pubmed/18538011
http://dx.doi.org/10.1186/1476-7120-6-28
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