Stabilizing mutation of CTNNB1/beta-catenin and protein accumulation analyzed in a large series of parathyroid tumors of Swedish patients

BACKGROUND: Aberrant accumulation of β-catenin plays an important role in a variety of human neoplasms. We recently reported accumulation of β-catenin in parathyroid adenomas from patients with primary hyperparathyroidism (pHPT). In CTNNB1 exon 3, we detected a stabilizing mutation (S37A) in 3 out o...

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Detalles Bibliográficos
Autores principales: Björklund, Peyman, Lindberg, Daniel, Åkerström, Göran, Westin, Gunnar
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435117/
https://www.ncbi.nlm.nih.gov/pubmed/18541010
http://dx.doi.org/10.1186/1476-4598-7-53

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435117/
https://www.ncbi.nlm.nih.gov/pubmed/18541010
http://dx.doi.org/10.1186/1476-4598-7-53

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