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The Role of the Entorhinal Cortex in Extinction: Influences of Aging
The entorhinal cortex is perhaps the area of the brain in which neurofibrillary tangles and amyloid plaques are first detectable in old age with or without mild cognitive impairment, and very particularly in Alzheimer's disease. It plays a key role in memory formation, retrieval, and extinction...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435227/ https://www.ncbi.nlm.nih.gov/pubmed/18584042 http://dx.doi.org/10.1155/2008/595282 |
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author | Bevilaqua, Lia R. M. Rossato, Janine I. Bonini, Juliana S. Myskiw, Jociane C. Clarke, Julia R. Monteiro, Siomara Lima, Ramón H. Medina, Jorge H. Cammarota, Martín Izquierdo, Iván |
author_facet | Bevilaqua, Lia R. M. Rossato, Janine I. Bonini, Juliana S. Myskiw, Jociane C. Clarke, Julia R. Monteiro, Siomara Lima, Ramón H. Medina, Jorge H. Cammarota, Martín Izquierdo, Iván |
author_sort | Bevilaqua, Lia R. M. |
collection | PubMed |
description | The entorhinal cortex is perhaps the area of the brain in which neurofibrillary tangles and amyloid plaques are first detectable in old age with or without mild cognitive impairment, and very particularly in Alzheimer's disease. It plays a key role in memory formation, retrieval, and extinction, as part of circuits that include the hippocampus, the amygdaloid nucleus, and several regions of the neocortex, in particular of the prefrontal cortex. Lesions or biochemical impairments of the entorhinal cortex hinder extinction. Microinfusion experiments have shown that glutamate NMDA receptors, calcium and calmodulin-dependent protein kinase II, and protein synthesis in the entorhinal cortex are involved in and required for extinction. Aging also hinders extinction; it is possible that its effect may be in part mediated by the entorhinal cortex. |
format | Text |
id | pubmed-2435227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-24352272008-06-26 The Role of the Entorhinal Cortex in Extinction: Influences of Aging Bevilaqua, Lia R. M. Rossato, Janine I. Bonini, Juliana S. Myskiw, Jociane C. Clarke, Julia R. Monteiro, Siomara Lima, Ramón H. Medina, Jorge H. Cammarota, Martín Izquierdo, Iván Neural Plast Review Article The entorhinal cortex is perhaps the area of the brain in which neurofibrillary tangles and amyloid plaques are first detectable in old age with or without mild cognitive impairment, and very particularly in Alzheimer's disease. It plays a key role in memory formation, retrieval, and extinction, as part of circuits that include the hippocampus, the amygdaloid nucleus, and several regions of the neocortex, in particular of the prefrontal cortex. Lesions or biochemical impairments of the entorhinal cortex hinder extinction. Microinfusion experiments have shown that glutamate NMDA receptors, calcium and calmodulin-dependent protein kinase II, and protein synthesis in the entorhinal cortex are involved in and required for extinction. Aging also hinders extinction; it is possible that its effect may be in part mediated by the entorhinal cortex. Hindawi Publishing Corporation 2008 2008-06-22 /pmc/articles/PMC2435227/ /pubmed/18584042 http://dx.doi.org/10.1155/2008/595282 Text en Copyright © 2008 Lia R. M. Bevilaqua et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bevilaqua, Lia R. M. Rossato, Janine I. Bonini, Juliana S. Myskiw, Jociane C. Clarke, Julia R. Monteiro, Siomara Lima, Ramón H. Medina, Jorge H. Cammarota, Martín Izquierdo, Iván The Role of the Entorhinal Cortex in Extinction: Influences of Aging |
title | The Role of the Entorhinal Cortex in Extinction: Influences of Aging |
title_full | The Role of the Entorhinal Cortex in Extinction: Influences of Aging |
title_fullStr | The Role of the Entorhinal Cortex in Extinction: Influences of Aging |
title_full_unstemmed | The Role of the Entorhinal Cortex in Extinction: Influences of Aging |
title_short | The Role of the Entorhinal Cortex in Extinction: Influences of Aging |
title_sort | role of the entorhinal cortex in extinction: influences of aging |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435227/ https://www.ncbi.nlm.nih.gov/pubmed/18584042 http://dx.doi.org/10.1155/2008/595282 |
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