Impact of point-mutations on the hybridization affinity of surface-bound DNA/DNA and RNA/DNA oligonucleotide-duplexes: Comparison of single base mismatches and base bulges

BACKGROUND: The high binding specificity of short 10 to 30 mer oligonucleotide probes enables single base mismatch (MM) discrimination and thus provides the basis for genotyping and resequencing microarray applications. Recent experiments indicate that the underlying principles governing DNA microar...

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Detalles Bibliográficos
Autores principales: Naiser, Thomas, Ehler, Oliver, Kayser, Jona, Mai, Timo, Michel, Wolfgang, Ott, Albrecht
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435543/
https://www.ncbi.nlm.nih.gov/pubmed/18477387
http://dx.doi.org/10.1186/1472-6750-8-48

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435543/
https://www.ncbi.nlm.nih.gov/pubmed/18477387
http://dx.doi.org/10.1186/1472-6750-8-48

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