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Developing and applying a gene functional association network for anti-angiogenic kinase inhibitor activity assessment in an angiogenesis co-culture model

BACKGROUND: Tumor angiogenesis is a highly regulated process involving intercellular communication as well as the interactions of multiple downstream signal transduction pathways. Disrupting one or even a few angiogenesis pathways is often insufficient to achieve sustained therapeutic benefits due t...

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Detalles Bibliográficos
Autores principales: Chen, Yuefeng, Wei, Tao, Yan, Lei, Lawrence, Frank, Qian, Hui-Rong, Burkholder, Timothy P, Starling, James J, Yingling, Jonathan M, Shou, Jianyong
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435557/
https://www.ncbi.nlm.nih.gov/pubmed/18518970
http://dx.doi.org/10.1186/1471-2164-9-264

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