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Novel Druggable Hot Spots in Avian Influenza Neuraminidase H5N1 Revealed by Computational Solvent Mapping of a Reduced and Representative Receptor Ensemble

The influenza virus subtype H5N1 has raised concerns of a possible human pandemic threat because of its high virulence and mutation rate. Although several approved anti-influenza drugs effectively target the neuraminidase, some strains have already acquired resistance to the currently available anti...

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Detalles Bibliográficos
Autores principales:	Landon, Melissa R, Amaro, Rommie E, Baron, Riccardo, Ngan, Chi Ho, Ozonoff, David, Andrew McCammon, J, Vajda, Sandor
Formato:	Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438278/ https://www.ncbi.nlm.nih.gov/pubmed/18205727 http://dx.doi.org/10.1111/j.1747-0285.2007.00614.x

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