Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways

Histone deacetylase (HDAC) inhibitors are a new class of chemotherapeutic agents. Our laboratory has recently reported that phenylhexyl isothiocyanate (PHI), a synthetic isothiocyanate, is an inhibitor of HDAC. In this study we examined whether PHI is a hypomethylating agent and its effects on myelo...

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Detalles Bibliográficos
Autores principales: Lu, Quanyi, Lin, Xianghua, Feng, Jean, Zhao, Xiangmin, Gallagher, Ruth, Lee, Marietta Y, Chiao, Jen-Wei, Liu, Delong
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438442/
https://www.ncbi.nlm.nih.gov/pubmed/18577263
http://dx.doi.org/10.1186/1756-8722-1-6

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