Targeted Disruption of the PME-1 Gene Causes Loss of Demethylated PP2A and Perinatal Lethality in Mice

BACKGROUND: Phosphoprotein phosphatase 2A (PP2A), a major serine-threonine protein phosphatase in eukaryotes, is an oligomeric protein comprised of structural (A) and catalytic (C) subunits to which a variable regulatory subunit (B) can associate. The C subunit contains a methyl ester post-translati...

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Detalles Bibliográficos
Autores principales: Ortega-Gutiérrez, Silvia, Leung, Donmienne, Ficarro, Scott, Peters, Eric C., Cravatt, Benjamin F.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438471/
https://www.ncbi.nlm.nih.gov/pubmed/18596935
http://dx.doi.org/10.1371/journal.pone.0002486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438471/
https://www.ncbi.nlm.nih.gov/pubmed/18596935
http://dx.doi.org/10.1371/journal.pone.0002486

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