Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone

BACKGROUND AND PURPOSE: Inhibition of cholesteryl ester transfer protein (CETP) with torcetrapib in humans increases plasma high density lipoprotein (HDL) cholesterol levels but is associated with increased blood pressure. In a phase 3 clinical study, evaluating the effects of torcetrapib in atheros...

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Detalles Bibliográficos
Autores principales: Forrest, M J, Bloomfield, D, Briscoe, R J, Brown, P N, Cumiskey, A-M, Ehrhart, J, Hershey, J C, Keller, W J, Ma, X, McPherson, H E, Messina, E, Peterson, L B, Sharif-Rodriguez, W, Siegl, P K S, Sinclair, P J, Sparrow, C P, Stevenson, A S, Sun, S-Y, Tsai, C, Vargas, H, Walker, M, West, S H, White, V, Woltmann, R F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440088/
https://www.ncbi.nlm.nih.gov/pubmed/18536749
http://dx.doi.org/10.1038/bjp.2008.229

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