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Bioactivation of Nitroglycerin by Purified Mitochondrial and Cytosolic Aldehyde Dehydrogenases

Metabolism of nitroglycerin (GTN) to 1,2-glycerol dinitrate (GDN) and nitrite by mitochondrial aldehyde dehydrogenase (ALDH2) is essentially involved in GTN bioactivation resulting in cyclic GMP-mediated vascular relaxation. The link between nitrite formation and activation of soluble guanylate cycl...

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Detalles Bibliográficos
Autores principales:	Beretta, Matteo, Gruber, Karl, Kollau, Alexander, Russwurm, Michael, Koesling, Doris, Goessler, Walter, Keung, Wing Ming, Schmidt, Kurt, Mayer, Bernd
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2008
Materias:	Enzyme Catalysis and Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440601/ https://www.ncbi.nlm.nih.gov/pubmed/18450747 http://dx.doi.org/10.1074/jbc.M801182200

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