Cargando…
A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men
SUMMARY: The activity index of stearoyl-CoA desaturase (SCD), a key enzyme in lipogenesis, was associated with increased risk of fracture in a longitudinal population-based cohort of men. This indicates that elevated levels of endogenous lipogenesis increase the risk of fracture and suggest a role f...
Autores principales: | , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440922/ https://www.ncbi.nlm.nih.gov/pubmed/18066610 http://dx.doi.org/10.1007/s00198-007-0521-y |
_version_ | 1782156584734949376 |
---|---|
author | Melhus, H. Risérus, U. Warensjö, E. Wernroth, L. Jensevik, K. Berglund, L. Vessby, B. Michaëlsson, K. |
author_facet | Melhus, H. Risérus, U. Warensjö, E. Wernroth, L. Jensevik, K. Berglund, L. Vessby, B. Michaëlsson, K. |
author_sort | Melhus, H. |
collection | PubMed |
description | SUMMARY: The activity index of stearoyl-CoA desaturase (SCD), a key enzyme in lipogenesis, was associated with increased risk of fracture in a longitudinal population-based cohort of men. This indicates that elevated levels of endogenous lipogenesis increase the risk of fracture and suggest a role for saturated fat in the pathogenesis of osteoporosis. INTRODUCTION: Osteoblasts and marrow adipocytes are derived from a common mesenchymal progenitor, and experimental studies have indicated that increased adipogenesis can occur at the expense of osteoblasts, leading to bone loss. Stearoyl-CoA desaturase (SCD) converts saturated to monounsaturated fatty acids and is a key enzyme in lipogenesis. METHODS: Analysis was performed in a population-based, longitudinal cohort study of men (n = 2009). A product-to-precursor index (palmitoleic acid/palmitic acid) was used to estimate SCD activity in fasting serum analyzed in samples obtained at enrollment at age 50 years. Fractures were documented in 422 men during 35 years of follow-up. Cox regression analysis was used to determine the risk of fracture according to SCD activity index. RESULTS: The risk of fracture was highest among men with the highest levels of SCD activity index. Multivariable analysis of the risk of fracture in the highest quintile as compared to the lowest one showed that the rate ratio was 1.71 (95% CI 1.26–2.33) for any fracture, with an estimated population attributable risk of 15%. The risk was further increased within the highest quintile. CONCLUSIONS: Our results indicate that elevated levels of endogenous lipogenesis increase the risk of fracture and suggest a role for saturated fat in the pathogenesis of osteoporosis. |
format | Text |
id | pubmed-2440922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-24409222008-06-27 A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men Melhus, H. Risérus, U. Warensjö, E. Wernroth, L. Jensevik, K. Berglund, L. Vessby, B. Michaëlsson, K. Osteoporos Int Original Article SUMMARY: The activity index of stearoyl-CoA desaturase (SCD), a key enzyme in lipogenesis, was associated with increased risk of fracture in a longitudinal population-based cohort of men. This indicates that elevated levels of endogenous lipogenesis increase the risk of fracture and suggest a role for saturated fat in the pathogenesis of osteoporosis. INTRODUCTION: Osteoblasts and marrow adipocytes are derived from a common mesenchymal progenitor, and experimental studies have indicated that increased adipogenesis can occur at the expense of osteoblasts, leading to bone loss. Stearoyl-CoA desaturase (SCD) converts saturated to monounsaturated fatty acids and is a key enzyme in lipogenesis. METHODS: Analysis was performed in a population-based, longitudinal cohort study of men (n = 2009). A product-to-precursor index (palmitoleic acid/palmitic acid) was used to estimate SCD activity in fasting serum analyzed in samples obtained at enrollment at age 50 years. Fractures were documented in 422 men during 35 years of follow-up. Cox regression analysis was used to determine the risk of fracture according to SCD activity index. RESULTS: The risk of fracture was highest among men with the highest levels of SCD activity index. Multivariable analysis of the risk of fracture in the highest quintile as compared to the lowest one showed that the rate ratio was 1.71 (95% CI 1.26–2.33) for any fracture, with an estimated population attributable risk of 15%. The risk was further increased within the highest quintile. CONCLUSIONS: Our results indicate that elevated levels of endogenous lipogenesis increase the risk of fracture and suggest a role for saturated fat in the pathogenesis of osteoporosis. Springer-Verlag 2007-12-08 2008 /pmc/articles/PMC2440922/ /pubmed/18066610 http://dx.doi.org/10.1007/s00198-007-0521-y Text en © The Author(s) 2007 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Original Article Melhus, H. Risérus, U. Warensjö, E. Wernroth, L. Jensevik, K. Berglund, L. Vessby, B. Michaëlsson, K. A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men |
title | A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men |
title_full | A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men |
title_fullStr | A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men |
title_full_unstemmed | A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men |
title_short | A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men |
title_sort | high activity index of stearoyl-coa desaturase is associated with increased risk of fracture in men |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440922/ https://www.ncbi.nlm.nih.gov/pubmed/18066610 http://dx.doi.org/10.1007/s00198-007-0521-y |
work_keys_str_mv | AT melhush ahighactivityindexofstearoylcoadesaturaseisassociatedwithincreasedriskoffractureinmen AT riserusu ahighactivityindexofstearoylcoadesaturaseisassociatedwithincreasedriskoffractureinmen AT warensjoe ahighactivityindexofstearoylcoadesaturaseisassociatedwithincreasedriskoffractureinmen AT wernrothl ahighactivityindexofstearoylcoadesaturaseisassociatedwithincreasedriskoffractureinmen AT jensevikk ahighactivityindexofstearoylcoadesaturaseisassociatedwithincreasedriskoffractureinmen AT berglundl ahighactivityindexofstearoylcoadesaturaseisassociatedwithincreasedriskoffractureinmen AT vessbyb ahighactivityindexofstearoylcoadesaturaseisassociatedwithincreasedriskoffractureinmen AT michaelssonk ahighactivityindexofstearoylcoadesaturaseisassociatedwithincreasedriskoffractureinmen AT melhush highactivityindexofstearoylcoadesaturaseisassociatedwithincreasedriskoffractureinmen AT riserusu highactivityindexofstearoylcoadesaturaseisassociatedwithincreasedriskoffractureinmen AT warensjoe highactivityindexofstearoylcoadesaturaseisassociatedwithincreasedriskoffractureinmen AT wernrothl highactivityindexofstearoylcoadesaturaseisassociatedwithincreasedriskoffractureinmen AT jensevikk highactivityindexofstearoylcoadesaturaseisassociatedwithincreasedriskoffractureinmen AT berglundl highactivityindexofstearoylcoadesaturaseisassociatedwithincreasedriskoffractureinmen AT vessbyb highactivityindexofstearoylcoadesaturaseisassociatedwithincreasedriskoffractureinmen AT michaelssonk highactivityindexofstearoylcoadesaturaseisassociatedwithincreasedriskoffractureinmen |