Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians

We performed a genome-wide association study with 23,465 microsatellite markers to identify genes related to adult height. Selective genotyping was applied to extremely tall and extremely short individuals from the Khalkh-Mongolian population. Two loci, 8q21.13 and 15q22.33, which showed the stronge...

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Autores principales: Kimura, Tetsuaki, Kobayashi, Terukazu, Munkhbat, Batmunkh, Oyungerel, Ganjuur, Bilegtsaikhan, Tsolmon, Anar, Damdinsuren, Jambaldorj, Jamiyansuren, Munkhsaikhan, Sodnom, Munkhtuvshin, Namid, Hayashi, Hideki, Oka, Akira, Inoue, Ituro, Inoko, Hidetoshi
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440952/
https://www.ncbi.nlm.nih.gov/pubmed/18491143
http://dx.doi.org/10.1007/s00439-008-0512-x
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author Kimura, Tetsuaki
Kobayashi, Terukazu
Munkhbat, Batmunkh
Oyungerel, Ganjuur
Bilegtsaikhan, Tsolmon
Anar, Damdinsuren
Jambaldorj, Jamiyansuren
Munkhsaikhan, Sodnom
Munkhtuvshin, Namid
Hayashi, Hideki
Oka, Akira
Inoue, Ituro
Inoko, Hidetoshi
author_facet Kimura, Tetsuaki
Kobayashi, Terukazu
Munkhbat, Batmunkh
Oyungerel, Ganjuur
Bilegtsaikhan, Tsolmon
Anar, Damdinsuren
Jambaldorj, Jamiyansuren
Munkhsaikhan, Sodnom
Munkhtuvshin, Namid
Hayashi, Hideki
Oka, Akira
Inoue, Ituro
Inoko, Hidetoshi
author_sort Kimura, Tetsuaki
collection PubMed
description We performed a genome-wide association study with 23,465 microsatellite markers to identify genes related to adult height. Selective genotyping was applied to extremely tall and extremely short individuals from the Khalkh-Mongolian population. Two loci, 8q21.13 and 15q22.33, which showed the strongest association with microsatellites were subjected to further analyses of SNPs in 782 tall and 773 short individuals. The most significant association was observed with SNP rs2220456 at 8q21.13 (P = 0.000016). In the LD block at 15q22.32, SNP rs8038652 located in intron 1 of IQCH was strongly associated (P = 0.0003), especially the AA genotype of the SNP under a recessive model was strongly associated with adult height (P = 0.000046).
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spelling pubmed-24409522008-06-27 Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians Kimura, Tetsuaki Kobayashi, Terukazu Munkhbat, Batmunkh Oyungerel, Ganjuur Bilegtsaikhan, Tsolmon Anar, Damdinsuren Jambaldorj, Jamiyansuren Munkhsaikhan, Sodnom Munkhtuvshin, Namid Hayashi, Hideki Oka, Akira Inoue, Ituro Inoko, Hidetoshi Hum Genet Short Report We performed a genome-wide association study with 23,465 microsatellite markers to identify genes related to adult height. Selective genotyping was applied to extremely tall and extremely short individuals from the Khalkh-Mongolian population. Two loci, 8q21.13 and 15q22.33, which showed the strongest association with microsatellites were subjected to further analyses of SNPs in 782 tall and 773 short individuals. The most significant association was observed with SNP rs2220456 at 8q21.13 (P = 0.000016). In the LD block at 15q22.32, SNP rs8038652 located in intron 1 of IQCH was strongly associated (P = 0.0003), especially the AA genotype of the SNP under a recessive model was strongly associated with adult height (P = 0.000046). Springer-Verlag 2008-05-20 2008 /pmc/articles/PMC2440952/ /pubmed/18491143 http://dx.doi.org/10.1007/s00439-008-0512-x Text en © The Author(s) 2008 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Short Report
Kimura, Tetsuaki
Kobayashi, Terukazu
Munkhbat, Batmunkh
Oyungerel, Ganjuur
Bilegtsaikhan, Tsolmon
Anar, Damdinsuren
Jambaldorj, Jamiyansuren
Munkhsaikhan, Sodnom
Munkhtuvshin, Namid
Hayashi, Hideki
Oka, Akira
Inoue, Ituro
Inoko, Hidetoshi
Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians
title Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians
title_full Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians
title_fullStr Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians
title_full_unstemmed Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians
title_short Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians
title_sort genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in mongolians
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440952/
https://www.ncbi.nlm.nih.gov/pubmed/18491143
http://dx.doi.org/10.1007/s00439-008-0512-x
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