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Clinical effects of transcatheter hepatic arterial embolization with holmium-166 poly(l-lactic acid) microspheres in healthy pigs
PURPOSE: The aim of this study is to evaluate the toxicity of holmium-166 poly(l-lactic acid) microspheres administered into the hepatic artery in pigs. METHODS: Healthy pigs (20–30 kg) were injected into the hepatic artery with holmium-165-loaded microspheres ((165)HoMS; n = 5) or with holmium-166-...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Springer-Verlag
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440967/ https://www.ncbi.nlm.nih.gov/pubmed/18330569 http://dx.doi.org/10.1007/s00259-008-0747-8 |
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author | Vente, M. A. D. Nijsen, J. F. W. de Wit, T. C. Seppenwoolde, J. H. Krijger, G. C. Seevinck, P. R. Huisman, A. Zonnenberg, B. A. van den Ingh, T. S. G. A. M. van het Schip, A. D. |
author_facet | Vente, M. A. D. Nijsen, J. F. W. de Wit, T. C. Seppenwoolde, J. H. Krijger, G. C. Seevinck, P. R. Huisman, A. Zonnenberg, B. A. van den Ingh, T. S. G. A. M. van het Schip, A. D. |
author_sort | Vente, M. A. D. |
collection | PubMed |
description | PURPOSE: The aim of this study is to evaluate the toxicity of holmium-166 poly(l-lactic acid) microspheres administered into the hepatic artery in pigs. METHODS: Healthy pigs (20–30 kg) were injected into the hepatic artery with holmium-165-loaded microspheres ((165)HoMS; n = 5) or with holmium-166-loaded microspheres ((166)HoMS; n = 13). The microspheres’ biodistribution was assessed by single-photon emission computed tomography and/or MRI. The animals were monitored clinically, biochemically, and ((166)HoMS group only) hematologically over a period of 1 month ((165)HoMS group) or over 1 or 2 months ((166)HoMS group). Finally, a pathological examination was undertaken. RESULTS: After microsphere administration, some animals exhibited a slightly diminished level of consciousness and a dip in appetite, both of which were transient. Four lethal adverse events occurred in the (166)HoMS group due either to incorrect administration or comorbidity: inadvertent delivery of microspheres into the gastric wall (n = 2), preexisting gastric ulceration (n = 1), and endocarditis (n = 1). AST levels were transitorily elevated post-(166)HoMS administration. In the other blood parameters, no abnormalities were observed. Nuclear scans were acquired from all animals from the (166)HoMS group, and MRI scans were performed if available. In pigs from the (166)HoMS group, atrophy of one or more liver lobes was frequently observed. The actual radioactivity distribution was assessed through ex vivo (166m)Ho measurements. CONCLUSION: It can be concluded that the toxicity profile of HoMS is low. In pigs, hepatic arterial embolization with (166)HoMS in amounts corresponding with liver-absorbed doses of over 100 Gy, if correctly administered, is not associated with clinically relevant side effects. This result offers a good perspective for upcoming patient trials. |
format | Text |
id | pubmed-2440967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-24409672008-06-27 Clinical effects of transcatheter hepatic arterial embolization with holmium-166 poly(l-lactic acid) microspheres in healthy pigs Vente, M. A. D. Nijsen, J. F. W. de Wit, T. C. Seppenwoolde, J. H. Krijger, G. C. Seevinck, P. R. Huisman, A. Zonnenberg, B. A. van den Ingh, T. S. G. A. M. van het Schip, A. D. Eur J Nucl Med Mol Imaging Original Article PURPOSE: The aim of this study is to evaluate the toxicity of holmium-166 poly(l-lactic acid) microspheres administered into the hepatic artery in pigs. METHODS: Healthy pigs (20–30 kg) were injected into the hepatic artery with holmium-165-loaded microspheres ((165)HoMS; n = 5) or with holmium-166-loaded microspheres ((166)HoMS; n = 13). The microspheres’ biodistribution was assessed by single-photon emission computed tomography and/or MRI. The animals were monitored clinically, biochemically, and ((166)HoMS group only) hematologically over a period of 1 month ((165)HoMS group) or over 1 or 2 months ((166)HoMS group). Finally, a pathological examination was undertaken. RESULTS: After microsphere administration, some animals exhibited a slightly diminished level of consciousness and a dip in appetite, both of which were transient. Four lethal adverse events occurred in the (166)HoMS group due either to incorrect administration or comorbidity: inadvertent delivery of microspheres into the gastric wall (n = 2), preexisting gastric ulceration (n = 1), and endocarditis (n = 1). AST levels were transitorily elevated post-(166)HoMS administration. In the other blood parameters, no abnormalities were observed. Nuclear scans were acquired from all animals from the (166)HoMS group, and MRI scans were performed if available. In pigs from the (166)HoMS group, atrophy of one or more liver lobes was frequently observed. The actual radioactivity distribution was assessed through ex vivo (166m)Ho measurements. CONCLUSION: It can be concluded that the toxicity profile of HoMS is low. In pigs, hepatic arterial embolization with (166)HoMS in amounts corresponding with liver-absorbed doses of over 100 Gy, if correctly administered, is not associated with clinically relevant side effects. This result offers a good perspective for upcoming patient trials. Springer-Verlag 2008-03-11 2008 /pmc/articles/PMC2440967/ /pubmed/18330569 http://dx.doi.org/10.1007/s00259-008-0747-8 Text en © The Author(s) 2008 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Original Article Vente, M. A. D. Nijsen, J. F. W. de Wit, T. C. Seppenwoolde, J. H. Krijger, G. C. Seevinck, P. R. Huisman, A. Zonnenberg, B. A. van den Ingh, T. S. G. A. M. van het Schip, A. D. Clinical effects of transcatheter hepatic arterial embolization with holmium-166 poly(l-lactic acid) microspheres in healthy pigs |
title | Clinical effects of transcatheter hepatic arterial embolization with holmium-166 poly(l-lactic acid) microspheres in healthy pigs |
title_full | Clinical effects of transcatheter hepatic arterial embolization with holmium-166 poly(l-lactic acid) microspheres in healthy pigs |
title_fullStr | Clinical effects of transcatheter hepatic arterial embolization with holmium-166 poly(l-lactic acid) microspheres in healthy pigs |
title_full_unstemmed | Clinical effects of transcatheter hepatic arterial embolization with holmium-166 poly(l-lactic acid) microspheres in healthy pigs |
title_short | Clinical effects of transcatheter hepatic arterial embolization with holmium-166 poly(l-lactic acid) microspheres in healthy pigs |
title_sort | clinical effects of transcatheter hepatic arterial embolization with holmium-166 poly(l-lactic acid) microspheres in healthy pigs |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440967/ https://www.ncbi.nlm.nih.gov/pubmed/18330569 http://dx.doi.org/10.1007/s00259-008-0747-8 |
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