Congenital diaphragmatic hernia and retinoids: searching for an etiology

Congenital diaphragmatic hernia (CDH) is a major life-threatening cause of respiratory failure in the newborn. Recent data reveal the role of a retinoid-signaling pathway disruption in the pathogenesis of CDH. We describe the epidemiology and pathophysiology of human CDH, the metabolism of retinoids...

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Detalles Bibliográficos
Autores principales: Montedonico, Sandra, Nakazawa, Nana, Puri, Prem
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440969/
https://www.ncbi.nlm.nih.gov/pubmed/18401587
http://dx.doi.org/10.1007/s00383-008-2140-x
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author Montedonico, Sandra
Nakazawa, Nana
Puri, Prem
author_facet Montedonico, Sandra
Nakazawa, Nana
Puri, Prem
author_sort Montedonico, Sandra
collection PubMed
description Congenital diaphragmatic hernia (CDH) is a major life-threatening cause of respiratory failure in the newborn. Recent data reveal the role of a retinoid-signaling pathway disruption in the pathogenesis of CDH. We describe the epidemiology and pathophysiology of human CDH, the metabolism of retinoids and the implications of retinoids in the development of the diaphragm and lung. Finally, we describe the existing evidence of a disruption of the retinoid-signaling pathway in CDH.
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spelling pubmed-24409692008-06-27 Congenital diaphragmatic hernia and retinoids: searching for an etiology Montedonico, Sandra Nakazawa, Nana Puri, Prem Pediatr Surg Int Review Article Congenital diaphragmatic hernia (CDH) is a major life-threatening cause of respiratory failure in the newborn. Recent data reveal the role of a retinoid-signaling pathway disruption in the pathogenesis of CDH. We describe the epidemiology and pathophysiology of human CDH, the metabolism of retinoids and the implications of retinoids in the development of the diaphragm and lung. Finally, we describe the existing evidence of a disruption of the retinoid-signaling pathway in CDH. Springer-Verlag 2008-04-10 2008 /pmc/articles/PMC2440969/ /pubmed/18401587 http://dx.doi.org/10.1007/s00383-008-2140-x Text en © The Author(s) 2008 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Review Article
Montedonico, Sandra
Nakazawa, Nana
Puri, Prem
Congenital diaphragmatic hernia and retinoids: searching for an etiology
title Congenital diaphragmatic hernia and retinoids: searching for an etiology
title_full Congenital diaphragmatic hernia and retinoids: searching for an etiology
title_fullStr Congenital diaphragmatic hernia and retinoids: searching for an etiology
title_full_unstemmed Congenital diaphragmatic hernia and retinoids: searching for an etiology
title_short Congenital diaphragmatic hernia and retinoids: searching for an etiology
title_sort congenital diaphragmatic hernia and retinoids: searching for an etiology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440969/
https://www.ncbi.nlm.nih.gov/pubmed/18401587
http://dx.doi.org/10.1007/s00383-008-2140-x
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