A role for Numb in p53 stabilization

The cell-fate determinant Numb has recently been shown to help activate the tumor suppressor protein p53. Loss of Numb in breast cancers would result, therefore, in both the activation of the potential oncogene Notch and the diminution of tumor suppression by p53.

Detalles Bibliográficos
Autores principales: Carter, Stephanie, Vousden, Karen H
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441455/
https://www.ncbi.nlm.nih.gov/pubmed/18492217
http://dx.doi.org/10.1186/gb-2008-9-5-221
Descripción
Sumario:The cell-fate determinant Numb has recently been shown to help activate the tumor suppressor protein p53. Loss of Numb in breast cancers would result, therefore, in both the activation of the potential oncogene Notch and the diminution of tumor suppression by p53.

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