A role for Numb in p53 stabilization

The cell-fate determinant Numb has recently been shown to help activate the tumor suppressor protein p53. Loss of Numb in breast cancers would result, therefore, in both the activation of the potential oncogene Notch and the diminution of tumor suppression by p53.

Detalles Bibliográficos
Autores principales: Carter, Stephanie, Vousden, Karen H
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441455/
https://www.ncbi.nlm.nih.gov/pubmed/18492217
http://dx.doi.org/10.1186/gb-2008-9-5-221
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author Carter, Stephanie
Vousden, Karen H
author_facet Carter, Stephanie
Vousden, Karen H
author_sort Carter, Stephanie
collection PubMed
description The cell-fate determinant Numb has recently been shown to help activate the tumor suppressor protein p53. Loss of Numb in breast cancers would result, therefore, in both the activation of the potential oncogene Notch and the diminution of tumor suppression by p53.
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spelling pubmed-24414552008-06-28 A role for Numb in p53 stabilization Carter, Stephanie Vousden, Karen H Genome Biol Minireview The cell-fate determinant Numb has recently been shown to help activate the tumor suppressor protein p53. Loss of Numb in breast cancers would result, therefore, in both the activation of the potential oncogene Notch and the diminution of tumor suppression by p53. BioMed Central 2008 2008-05-09 /pmc/articles/PMC2441455/ /pubmed/18492217 http://dx.doi.org/10.1186/gb-2008-9-5-221 Text en Copyright © 2008 BioMed Central Ltd
spellingShingle Minireview
Carter, Stephanie
Vousden, Karen H
A role for Numb in p53 stabilization
title A role for Numb in p53 stabilization
title_full A role for Numb in p53 stabilization
title_fullStr A role for Numb in p53 stabilization
title_full_unstemmed A role for Numb in p53 stabilization
title_short A role for Numb in p53 stabilization
title_sort role for numb in p53 stabilization
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441455/
https://www.ncbi.nlm.nih.gov/pubmed/18492217
http://dx.doi.org/10.1186/gb-2008-9-5-221
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