Cargando…

Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children

BACKGROUND: Combination antimalarial therapy is recommended for the treatment of uncomplicated falciparum malaria in Africa; however, some concerns about the safety and tolerability of new regimens remain. This study compared the safety and tolerability of three combination antimalarial regimens in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maiteki-Sebuguzi, Catherine, Jagannathan, Prasanna, Yau, Vincent M, Clark, Tamara D, Njama-Meya, Denise, Nzarubara, Bridget, Talisuna, Ambrose O, Kamya, Moses R, Rosenthal, Philip J, Dorsey, Grant, Staedke, Sarah G
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441629/ https://www.ncbi.nlm.nih.gov/pubmed/18547415 http://dx.doi.org/10.1186/1475-2875-7-106

Ejemplares similares

Incidence of Malaria and Efficacy of Combination Antimalarial Therapies over 4 Years in an Urban Cohort of Ugandan Children
por: Clark, Tamara D., et al.
Publicado: (2010)

Monitoring antimalarial safety and tolerability in clinical trials: A case study from Uganda
por: Staedke, Sarah G, et al.
Publicado: (2008)

Treatment of malaria restricted to laboratory-confirmed cases: a prospective cohort study in Ugandan children
por: Njama-Meya, Denise, et al.
Publicado: (2007)

Early parasite clearance following artemisinin-based combination therapy among Ugandan children with uncomplicated Plasmodium falciparum malaria
por: Muhindo, Mary K, et al.
Publicado: (2014)

Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial
por: Achan, Jane, et al.
Publicado: (2009)

Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children
por: Jensen, Trevor P, et al.
Publicado: (2009)

Longitudinal study of urban malaria in a cohort of Ugandan children: description of study site, census and recruitment
por: Davis, Jennifer C, et al.
Publicado: (2006)

Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria in Uganda
por: Bukirwa, Hasifa, et al.
Publicado: (2006)

Efficacy and Safety of Fixed-Dose Artesunate-Amodiaquine vs. Artemether-Lumefantrine for Repeated Treatment of Uncomplicated Malaria in Ugandan Children
por: Yeka, Adoke, et al.
Publicado: (2014)

Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for Treating Uncomplicated Malaria: A Randomized Trial to Guide Policy in Uganda
por: Yeka, Adoke, et al.
Publicado: (2008)

Pharmacovigilance of antimalarial treatment in Africa: is it possible?
por: Talisuna, Ambrose O, et al.
Publicado: (2006)

Artemisinin versus Nonartemisinin Combination Therapy for Uncomplicated Malaria: Randomized Clinical Trials from Four Sites in Uganda
por: Yeka, Adoke, et al.
Publicado: (2005)

Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline
por: Kreutzfeld, Oriana, et al.
Publicado: (2023)

The PRIME trial protocol: evaluating the impact of an intervention implemented in public health centres on management of malaria and health outcomes of children using a cluster-randomised design in Tororo, Uganda
por: Staedke, Sarah G, et al.
Publicado: (2013)

Efficacy of Quinine, Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine as Rescue Treatment for Uncomplicated Malaria in Ugandan Children
por: Yeka, Adoke, et al.
Publicado: (2013)

Protective Efficacy and Safety of Three Antimalarial Regimens for the Prevention of Malaria in Young Ugandan Children: A Randomized Controlled Trial
por: Bigira, Victor, et al.
Publicado: (2014)

Associations between Antibodies to a Panel of Plasmodium falciparum Specific Antigens and Response to Sub-Optimal Antimalarial Therapy in Kampala, Uganda
por: Keh, Chris E., et al.
Publicado: (2012)

Polymorphisms in K13 and Falcipain-2 Associated with Artemisinin Resistance Are Not Prevalent in Plasmodium falciparum Isolated from Ugandan Children
por: Conrad, Melissa D., et al.
Publicado: (2014)

Bacteremia among Febrile Ugandan Children Treated with Antimalarials Despite a Negative Malaria Test
por: Kibuuka, Afizi, et al.
Publicado: (2015)

LLIN Evaluation in Uganda Project (LLINEUP) – Impact of long-lasting insecticidal nets with, and without, piperonyl butoxide on malaria indicators in Uganda: study protocol for a cluster-randomised trial
por: Staedke, Sarah G., et al.
Publicado: (2019)

LLIN Evaluation in Uganda Project (LLINEUP): a cross-sectional survey of species diversity and insecticide resistance in 48 districts of Uganda
por: Lynd, Amy, et al.
Publicado: (2019)

Impact of Intermittent Preventive Treatment With Dihydroartemisinin-Piperaquine on Malaria in Ugandan Schoolchildren: A Randomized, Placebo-Controlled Trial
por: Nankabirwa, Joaniter I., et al.
Publicado: (2014)

Characterizing pyrethroid resistance and mechanisms in Anopheles gambiae (s.s.) and Anopheles arabiensis from 11 districts in Uganda
por: Mawejje, Henry Ddumba, et al.
Publicado: (2022)

Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children
por: Sundell, Kerstin, et al.
Publicado: (2015)

Generation of a malaria negative Ugandan birth weight standard for the diagnosis of small for gestational age
por: Zakama, Arthurine K., et al.
Publicado: (2020)

Intermittent preventive treatment of malaria delivered to primary schoolchildren provided effective individual protection in Jinja, Uganda: secondary outcomes of a cluster-randomized trial (START-IPT)
por: Rehman, Andrea M., et al.
Publicado: (2019)

The impact of an intervention to introduce malaria rapid diagnostic tests on fever case management in a high transmission setting in Uganda: A mixed-methods cluster-randomized trial (PRIME)
por: Chandler, Clare I. R., et al.
Publicado: (2017)

Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children
por: Wallender, Erika, et al.
Publicado: (2021)

Sex-based differences in clearance of chronic Plasmodium falciparum infection
por: Briggs, Jessica, et al.
Publicado: (2020)

LLIN Evaluation in Uganda Project (LLINEUP): factors associated with ownership and use of long-lasting insecticidal nets in Uganda: a cross-sectional survey of 48 districts
por: Gonahasa, Samuel, et al.
Publicado: (2018)

Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance
por: Gasasira, Anne F, et al.
Publicado: (2010)

Assessment of community-level effects of intermittent preventive treatment for malaria in schoolchildren in Jinja, Uganda (START-IPT trial): a cluster-randomised trial
por: Staedke, Sarah G, et al.
Publicado: (2018)

LLIN Evaluation in Uganda Project (LLINEUP): factors associated with childhood parasitaemia and anaemia 3 years after a national long-lasting insecticidal net distribution campaign: a cross-sectional survey
por: Rugnao, Sheila, et al.
Publicado: (2019)

Artemether-Lumefantrine Pharmacokinetics and Clinical Response Are Minimally Altered in Pregnant Ugandan Women Treated for Uncomplicated Falciparum Malaria
por: Nyunt, Myaing M., et al.
Publicado: (2016)

Marked reduction in antibiotic usage following intensive malaria control in a cohort of Ugandan children
por: Krezanoski, Paul J., et al.
Publicado: (2021)

Effect of long-lasting insecticidal nets with and without piperonyl butoxide on malaria indicators in Uganda (LLINEUP): a pragmatic, cluster-randomised trial embedded in a national LLIN distribution campaign
por: Staedke, Sarah G, et al.
Publicado: (2020)

Some considerations in the design and interpretation of antimalarial drug trials in uncomplicated falciparum malaria
por: Stepniewska, Kasia, et al.
Publicado: (2006)

Study protocol for a randomised controlled double-blinded trial of the dose-dependent efficacy and safety of primaquine for clearance of gametocytes in children with uncomplicated falciparum malaria in Uganda
por: Eziefula, Alice Chijioke, et al.
Publicado: (2013)

Brief Report: Food Insufficiency Is Associated With Lack of Sustained Viral Suppression Among HIV-Infected Pregnant and Breastfeeding Ugandan Women
por: Koss, Catherine A., et al.
Publicado: (2016)

Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for Treatment of Malaria: A Randomized Trial
por: Kamya, Moses R, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_dc1bgbmb5sldbih737gspjgc5f