Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavage

The bleomycins (BLMs) are a family of natural glycopeptides used clinically as antitumor agents. In the presence of required cofactors (Fe(2+) and O(2)), BLM causes both single-stranded (ss) and double-stranded (ds) DNA damage with the latter thought to be the major source of cytotoxicity. Previous...

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Detalles Bibliográficos
Autores principales: Chen, Jingyang, Ghorai, Manas K., Kenney, Grace, Stubbe, JoAnne
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441780/
https://www.ncbi.nlm.nih.gov/pubmed/18492718
http://dx.doi.org/10.1093/nar/gkn302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441780/
https://www.ncbi.nlm.nih.gov/pubmed/18492718
http://dx.doi.org/10.1093/nar/gkn302

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