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Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins

The human KRAS proto-oncogene contains a critical nuclease hypersensitive element (NHE) upstream of the major transcription initiation site. In this article, we demonstrate by primer-extension experiments, PAGE, chemical footprinting, CD, UV and FRET experiments that the G-rich strand of NHE (32R) f...

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Detalles Bibliográficos
Autores principales:	Cogoi, Susanna, Paramasivam, Manikandan, Spolaore, Barbara, Xodo, Luigi E.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441797/ https://www.ncbi.nlm.nih.gov/pubmed/18490377 http://dx.doi.org/10.1093/nar/gkn120

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