Molecular basis for the lack of enantioselectivity of human 3-phosphoglycerate kinase

Non-natural l-nucleoside analogues are increasingly used as therapeutic agents to treat cancer and viral infections. To be active, l-nucleosides need to be phosphorylated to their respective triphosphate metabolites. This stepwise phosphorylation relies on human enzymes capable of processing l-nucle...

Descripción completa

Detalles Bibliográficos
Autores principales: Gondeau, C., Chaloin, L., Lallemand, P., Roy, B., Périgaud, C., Barman, T., Varga, A., Vas, M., Lionne, C., Arold, S. T.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441801/
https://www.ncbi.nlm.nih.gov/pubmed/18463139
http://dx.doi.org/10.1093/nar/gkn212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441801/
https://www.ncbi.nlm.nih.gov/pubmed/18463139
http://dx.doi.org/10.1093/nar/gkn212

Ejemplares similares