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Molecular basis for the lack of enantioselectivity of human 3-phosphoglycerate kinase
Non-natural l-nucleoside analogues are increasingly used as therapeutic agents to treat cancer and viral infections. To be active, l-nucleosides need to be phosphorylated to their respective triphosphate metabolites. This stepwise phosphorylation relies on human enzymes capable of processing l-nucle...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441801/ https://www.ncbi.nlm.nih.gov/pubmed/18463139 http://dx.doi.org/10.1093/nar/gkn212 |