Interferon alfacon 1 inhibits SARS-CoV infection in human bronchial epithelial Calu-3 cells

The primary targets for SARS-CoV infection are the epithelial cells in the respiratory and intestinal tract. The angiotensin-converting enzyme 2 (ACE-2) has been identified as a functional receptor for SARS-CoV. ACE-2 has been shown to be expressed at the apical domain of polarized Calu-3 cells. In...

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Detalles Bibliográficos
Autores principales: Kumaki, Yohichi, Day, Craig W., Wandersee, Miles K., Schow, Bradley P., Madsen, Justin S., Grant, Dixon, Roth, Jason P., Smee, Donald F., Blatt, Lawrence M., Barnard, Dale L.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Inc. Published by Elsevier Inc. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441846/
https://www.ncbi.nlm.nih.gov/pubmed/18406349
http://dx.doi.org/10.1016/j.bbrc.2008.04.006
Descripción
Sumario:The primary targets for SARS-CoV infection are the epithelial cells in the respiratory and intestinal tract. The angiotensin-converting enzyme 2 (ACE-2) has been identified as a functional receptor for SARS-CoV. ACE-2 has been shown to be expressed at the apical domain of polarized Calu-3 cells. In this report, interferon alfacon 1 was examined for inhibitory activities against SARS-CoV on human lung carcinoma epithelial Calu-3 cell line and the other three African green monkey kidney epithelial cell lines. Interferon alfacon 1 demonstrated significant antiviral activity in neutral red uptake assay and virus yield reduction assay. The data might provide an important insight into the mechanism of pathogenesis of SARS-CoV allowing further development of antiviral therapies for treating SARS infections.

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