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Comparative study of the stability of bimatoprost 0.03% and latanoprost 0.005%: A patient-use study
BACKGROUND: The stability of ophthalmic preparations in multidose containers is influenced by the preservative as well as the stability of the active ingredient. Unstable drugs may require refrigeration to preserve their active ingredient level and they are more likely to degrade over time, therefor...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442051/ https://www.ncbi.nlm.nih.gov/pubmed/18547433 http://dx.doi.org/10.1186/1471-2415-8-11 |
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author | Paolera, Mauricio D Kasahara, Niro Umbelino, Cristiano C Walt, John G |
author_facet | Paolera, Mauricio D Kasahara, Niro Umbelino, Cristiano C Walt, John G |
author_sort | Paolera, Mauricio D |
collection | PubMed |
description | BACKGROUND: The stability of ophthalmic preparations in multidose containers is influenced by the preservative as well as the stability of the active ingredient. Unstable drugs may require refrigeration to preserve their active ingredient level and they are more likely to degrade over time, therefore becoming more susceptible to degradation based on patient mishandling. The purpose of this study was to determine the degree of molecular degradation that occurs in bimatoprost and latanoprost in a patient-use setting. METHODS: This was an open-label, laboratory evaluation of the relative stability of bimatoprost and latanoprost. Patients presently using bimatoprost (n = 31) or latanoprost (n = 34) were identified at 2 clinical sites in Brazil. Patients were instructed to use and store their drops as usual and return all used medication bottles between day 28 and day 34 after opening. RESULTS: Bimatoprost demonstrated no degradation, but latanoprost degraded at various levels. The mean age of bimatoprost was 43.0 ± 3.4 days and the mean age of latanoprost was 43.9 ± 2.8 days (P = .072). The mean percentage of labeled concentration was 103.7% in the bimatoprost bottles and 88.1% in the latanoprost bottles (P < 001). CONCLUSION: This study showed that bimatoprost maintained ≥100% concentration throughout the study period while latanoprost did not. |
format | Text |
id | pubmed-2442051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-24420512008-07-01 Comparative study of the stability of bimatoprost 0.03% and latanoprost 0.005%: A patient-use study Paolera, Mauricio D Kasahara, Niro Umbelino, Cristiano C Walt, John G BMC Ophthalmol Research Article BACKGROUND: The stability of ophthalmic preparations in multidose containers is influenced by the preservative as well as the stability of the active ingredient. Unstable drugs may require refrigeration to preserve their active ingredient level and they are more likely to degrade over time, therefore becoming more susceptible to degradation based on patient mishandling. The purpose of this study was to determine the degree of molecular degradation that occurs in bimatoprost and latanoprost in a patient-use setting. METHODS: This was an open-label, laboratory evaluation of the relative stability of bimatoprost and latanoprost. Patients presently using bimatoprost (n = 31) or latanoprost (n = 34) were identified at 2 clinical sites in Brazil. Patients were instructed to use and store their drops as usual and return all used medication bottles between day 28 and day 34 after opening. RESULTS: Bimatoprost demonstrated no degradation, but latanoprost degraded at various levels. The mean age of bimatoprost was 43.0 ± 3.4 days and the mean age of latanoprost was 43.9 ± 2.8 days (P = .072). The mean percentage of labeled concentration was 103.7% in the bimatoprost bottles and 88.1% in the latanoprost bottles (P < 001). CONCLUSION: This study showed that bimatoprost maintained ≥100% concentration throughout the study period while latanoprost did not. BioMed Central 2008-06-11 /pmc/articles/PMC2442051/ /pubmed/18547433 http://dx.doi.org/10.1186/1471-2415-8-11 Text en Copyright © 2008 Paolera et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Paolera, Mauricio D Kasahara, Niro Umbelino, Cristiano C Walt, John G Comparative study of the stability of bimatoprost 0.03% and latanoprost 0.005%: A patient-use study |
title | Comparative study of the stability of bimatoprost 0.03% and latanoprost 0.005%: A patient-use study |
title_full | Comparative study of the stability of bimatoprost 0.03% and latanoprost 0.005%: A patient-use study |
title_fullStr | Comparative study of the stability of bimatoprost 0.03% and latanoprost 0.005%: A patient-use study |
title_full_unstemmed | Comparative study of the stability of bimatoprost 0.03% and latanoprost 0.005%: A patient-use study |
title_short | Comparative study of the stability of bimatoprost 0.03% and latanoprost 0.005%: A patient-use study |
title_sort | comparative study of the stability of bimatoprost 0.03% and latanoprost 0.005%: a patient-use study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442051/ https://www.ncbi.nlm.nih.gov/pubmed/18547433 http://dx.doi.org/10.1186/1471-2415-8-11 |
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