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Interactions between APP secretases and inflammatory mediators

There is now a large body of evidence linking inflammation to Alzheimer's disease (AD). This association manifests itself neuropathologically in the presence of activated microglia and astrocytes around neuritic plaques and increased levels of inflammatory mediators in the brains of AD patients...

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Detalles Bibliográficos
Autores principales: Sastre, Magdalena, Walter, Jochen, Gentleman, Steve M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442055/
https://www.ncbi.nlm.nih.gov/pubmed/18564425
http://dx.doi.org/10.1186/1742-2094-5-25
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author Sastre, Magdalena
Walter, Jochen
Gentleman, Steve M
author_facet Sastre, Magdalena
Walter, Jochen
Gentleman, Steve M
author_sort Sastre, Magdalena
collection PubMed
description There is now a large body of evidence linking inflammation to Alzheimer's disease (AD). This association manifests itself neuropathologically in the presence of activated microglia and astrocytes around neuritic plaques and increased levels of inflammatory mediators in the brains of AD patients. It is considered that amyloid-β peptide (Aβ), which is derived from the processing of the longer amyloid precursor protein (APP), could be the most important stimulator of this response, and therefore determining the role of the different secretases involved in its generation is essential for a better understanding of the regulation of inflammation in AD. The finding that certain non-steroidal anti-inflammatory drugs (NSAIDs) can affect the processing of APP by inhibiting β- and γ-secretases, together with recent revelations that these enzymes may be regulated by inflammation, suggest that they could be an interesting target for anti-inflammatory drugs. In this review we will discuss some of these issues and the role of the secretases in inflammation, independent of their effect on Aβ formation.
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spelling pubmed-24420552008-07-01 Interactions between APP secretases and inflammatory mediators Sastre, Magdalena Walter, Jochen Gentleman, Steve M J Neuroinflammation Review There is now a large body of evidence linking inflammation to Alzheimer's disease (AD). This association manifests itself neuropathologically in the presence of activated microglia and astrocytes around neuritic plaques and increased levels of inflammatory mediators in the brains of AD patients. It is considered that amyloid-β peptide (Aβ), which is derived from the processing of the longer amyloid precursor protein (APP), could be the most important stimulator of this response, and therefore determining the role of the different secretases involved in its generation is essential for a better understanding of the regulation of inflammation in AD. The finding that certain non-steroidal anti-inflammatory drugs (NSAIDs) can affect the processing of APP by inhibiting β- and γ-secretases, together with recent revelations that these enzymes may be regulated by inflammation, suggest that they could be an interesting target for anti-inflammatory drugs. In this review we will discuss some of these issues and the role of the secretases in inflammation, independent of their effect on Aβ formation. BioMed Central 2008-06-18 /pmc/articles/PMC2442055/ /pubmed/18564425 http://dx.doi.org/10.1186/1742-2094-5-25 Text en Copyright © 2008 Sastre et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Sastre, Magdalena
Walter, Jochen
Gentleman, Steve M
Interactions between APP secretases and inflammatory mediators
title Interactions between APP secretases and inflammatory mediators
title_full Interactions between APP secretases and inflammatory mediators
title_fullStr Interactions between APP secretases and inflammatory mediators
title_full_unstemmed Interactions between APP secretases and inflammatory mediators
title_short Interactions between APP secretases and inflammatory mediators
title_sort interactions between app secretases and inflammatory mediators
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442055/
https://www.ncbi.nlm.nih.gov/pubmed/18564425
http://dx.doi.org/10.1186/1742-2094-5-25
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