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Interactions between APP secretases and inflammatory mediators
There is now a large body of evidence linking inflammation to Alzheimer's disease (AD). This association manifests itself neuropathologically in the presence of activated microglia and astrocytes around neuritic plaques and increased levels of inflammatory mediators in the brains of AD patients...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442055/ https://www.ncbi.nlm.nih.gov/pubmed/18564425 http://dx.doi.org/10.1186/1742-2094-5-25 |
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author | Sastre, Magdalena Walter, Jochen Gentleman, Steve M |
author_facet | Sastre, Magdalena Walter, Jochen Gentleman, Steve M |
author_sort | Sastre, Magdalena |
collection | PubMed |
description | There is now a large body of evidence linking inflammation to Alzheimer's disease (AD). This association manifests itself neuropathologically in the presence of activated microglia and astrocytes around neuritic plaques and increased levels of inflammatory mediators in the brains of AD patients. It is considered that amyloid-β peptide (Aβ), which is derived from the processing of the longer amyloid precursor protein (APP), could be the most important stimulator of this response, and therefore determining the role of the different secretases involved in its generation is essential for a better understanding of the regulation of inflammation in AD. The finding that certain non-steroidal anti-inflammatory drugs (NSAIDs) can affect the processing of APP by inhibiting β- and γ-secretases, together with recent revelations that these enzymes may be regulated by inflammation, suggest that they could be an interesting target for anti-inflammatory drugs. In this review we will discuss some of these issues and the role of the secretases in inflammation, independent of their effect on Aβ formation. |
format | Text |
id | pubmed-2442055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-24420552008-07-01 Interactions between APP secretases and inflammatory mediators Sastre, Magdalena Walter, Jochen Gentleman, Steve M J Neuroinflammation Review There is now a large body of evidence linking inflammation to Alzheimer's disease (AD). This association manifests itself neuropathologically in the presence of activated microglia and astrocytes around neuritic plaques and increased levels of inflammatory mediators in the brains of AD patients. It is considered that amyloid-β peptide (Aβ), which is derived from the processing of the longer amyloid precursor protein (APP), could be the most important stimulator of this response, and therefore determining the role of the different secretases involved in its generation is essential for a better understanding of the regulation of inflammation in AD. The finding that certain non-steroidal anti-inflammatory drugs (NSAIDs) can affect the processing of APP by inhibiting β- and γ-secretases, together with recent revelations that these enzymes may be regulated by inflammation, suggest that they could be an interesting target for anti-inflammatory drugs. In this review we will discuss some of these issues and the role of the secretases in inflammation, independent of their effect on Aβ formation. BioMed Central 2008-06-18 /pmc/articles/PMC2442055/ /pubmed/18564425 http://dx.doi.org/10.1186/1742-2094-5-25 Text en Copyright © 2008 Sastre et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Sastre, Magdalena Walter, Jochen Gentleman, Steve M Interactions between APP secretases and inflammatory mediators |
title | Interactions between APP secretases and inflammatory mediators |
title_full | Interactions between APP secretases and inflammatory mediators |
title_fullStr | Interactions between APP secretases and inflammatory mediators |
title_full_unstemmed | Interactions between APP secretases and inflammatory mediators |
title_short | Interactions between APP secretases and inflammatory mediators |
title_sort | interactions between app secretases and inflammatory mediators |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442055/ https://www.ncbi.nlm.nih.gov/pubmed/18564425 http://dx.doi.org/10.1186/1742-2094-5-25 |
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