The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the Apc(Min/+ )mouse small intestine

BACKGROUND: Alterations in gene splicing occur in human sporadic colorectal cancer (CRC) and may contribute to tumour progression. The K-ras proto-oncogene encodes two splice variants, K-ras 4A and 4B, and K-ras activating mutations which jointly affect both isoforms are prevalent in CRC. Past studi...

Descripción completa

Detalles Bibliográficos
Autores principales: Patek, Charles E, Arends, Mark J, Rose, Lorraine, Luo, Feijun, Walker, Marion, Devenney, Paul S, Berry, Rachel L, Lawrence, Nicola J, Ridgway, Rachel A, Sansom, Owen J, Hooper, Martin L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442095/
https://www.ncbi.nlm.nih.gov/pubmed/18554389
http://dx.doi.org/10.1186/1471-230X-8-24

Ejemplares similares

Ejemplares similares