Cargando…

Pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study

BACKGROUND: This study intended to investigate whether residence in areas polluted by heavy industry, waste incineration, a high density of traffic and housing or intensive use of pesticides, could contribute to the high incidence of cancer observed in Flanders. METHODS: Subjects were 1583 residents...

Descripción completa

Detalles Bibliográficos
Autores principales: De Coster, Sam, Koppen, Gudrun, Bracke, Marc, Schroijen, Carmen, Den Hond, Elly, Nelen, Vera, Van de Mieroop, Els, Bruckers, Liesbeth, Bilau, Maaike, Baeyens, Willy, Schoeters, Greet, van Larebeke, Nik
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442593/
https://www.ncbi.nlm.nih.gov/pubmed/18522717
http://dx.doi.org/10.1186/1476-069X-7-26
_version_ 1782156707237986304
author De Coster, Sam
Koppen, Gudrun
Bracke, Marc
Schroijen, Carmen
Den Hond, Elly
Nelen, Vera
Van de Mieroop, Els
Bruckers, Liesbeth
Bilau, Maaike
Baeyens, Willy
Schoeters, Greet
van Larebeke, Nik
author_facet De Coster, Sam
Koppen, Gudrun
Bracke, Marc
Schroijen, Carmen
Den Hond, Elly
Nelen, Vera
Van de Mieroop, Els
Bruckers, Liesbeth
Bilau, Maaike
Baeyens, Willy
Schoeters, Greet
van Larebeke, Nik
author_sort De Coster, Sam
collection PubMed
description BACKGROUND: This study intended to investigate whether residence in areas polluted by heavy industry, waste incineration, a high density of traffic and housing or intensive use of pesticides, could contribute to the high incidence of cancer observed in Flanders. METHODS: Subjects were 1583 residents aged 50–65 from 9 areas with different types of pollution. Cadmium, lead, p,p'-DDE, hexachlorobenzene, PCBs and dioxin-like activity (Calux test) were measured in blood, and cadmium, t,t'-muconic acid and 1-hydroxypyrene in urine. Effect biomarkers were prostate specific antigen, carcinoembryonic antigen and p53 protein serum levels, number of micronuclei per 1000 binucleated peripheral blood cells, DNA damage (comet assay) in peripheral blood cells and 8-hydroxy-deoxyguanosine in urine. Confounding factors were taken into account. RESULTS: Overall significant differences between areas were found for carcinoembryonic antigen, micronuclei, 8-hydroxy-deoxyguanosine and DNA damage. Compared to a rural area with mainly fruit production, effect biomarkers were often significantly elevated around waste incinerators, in the cities of Antwerp and Ghent, in industrial areas and also in other rural areas. Within an industrial area DNA strand break levels were almost three times higher close to industrial installations than 5 kilometres upwind of the main industrial installations (p < 0.0001). Positive exposure-effect relationships were found for carcinoembryonic antigen (urinary cadmium, t,t'-muconic acid, 1-hydroxypyrene and blood lead), micronuclei (PCB118), DNA damage (PCB118) and 8-hydroxy-deoxyguanosine (t,t'-muconic acid, 1-hydroxypyrene). Also, we found significant associations between values of PSA above the p90 and higher values of urinary cadmium, between values of p53 above the p90 and higher serum levels of p,p'-DDE, hexachlorobenzene and marker PCBs (PCB 138, 153 and 180) and between serum levels of p,p'-DDE above the p90 and higher serum values of carcinoembryonic antigen. Significant associations were also found between effect biomarkers and occupational or lifestyle parameters. CONCLUSION: Levels of internal exposure, and residence near waste incinerators, in cities, or close to important industries, but not in areas with intensive use of pesticides, showed positive correlations with biomarkers associated with carcinogenesis and thus probably contribute to risk of cancer. In some rural areas, the levels of these biomarkers were not lower than in the rest of Flanders.
format Text
id pubmed-2442593
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-24425932008-07-02 Pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study De Coster, Sam Koppen, Gudrun Bracke, Marc Schroijen, Carmen Den Hond, Elly Nelen, Vera Van de Mieroop, Els Bruckers, Liesbeth Bilau, Maaike Baeyens, Willy Schoeters, Greet van Larebeke, Nik Environ Health Research BACKGROUND: This study intended to investigate whether residence in areas polluted by heavy industry, waste incineration, a high density of traffic and housing or intensive use of pesticides, could contribute to the high incidence of cancer observed in Flanders. METHODS: Subjects were 1583 residents aged 50–65 from 9 areas with different types of pollution. Cadmium, lead, p,p'-DDE, hexachlorobenzene, PCBs and dioxin-like activity (Calux test) were measured in blood, and cadmium, t,t'-muconic acid and 1-hydroxypyrene in urine. Effect biomarkers were prostate specific antigen, carcinoembryonic antigen and p53 protein serum levels, number of micronuclei per 1000 binucleated peripheral blood cells, DNA damage (comet assay) in peripheral blood cells and 8-hydroxy-deoxyguanosine in urine. Confounding factors were taken into account. RESULTS: Overall significant differences between areas were found for carcinoembryonic antigen, micronuclei, 8-hydroxy-deoxyguanosine and DNA damage. Compared to a rural area with mainly fruit production, effect biomarkers were often significantly elevated around waste incinerators, in the cities of Antwerp and Ghent, in industrial areas and also in other rural areas. Within an industrial area DNA strand break levels were almost three times higher close to industrial installations than 5 kilometres upwind of the main industrial installations (p < 0.0001). Positive exposure-effect relationships were found for carcinoembryonic antigen (urinary cadmium, t,t'-muconic acid, 1-hydroxypyrene and blood lead), micronuclei (PCB118), DNA damage (PCB118) and 8-hydroxy-deoxyguanosine (t,t'-muconic acid, 1-hydroxypyrene). Also, we found significant associations between values of PSA above the p90 and higher values of urinary cadmium, between values of p53 above the p90 and higher serum levels of p,p'-DDE, hexachlorobenzene and marker PCBs (PCB 138, 153 and 180) and between serum levels of p,p'-DDE above the p90 and higher serum values of carcinoembryonic antigen. Significant associations were also found between effect biomarkers and occupational or lifestyle parameters. CONCLUSION: Levels of internal exposure, and residence near waste incinerators, in cities, or close to important industries, but not in areas with intensive use of pesticides, showed positive correlations with biomarkers associated with carcinogenesis and thus probably contribute to risk of cancer. In some rural areas, the levels of these biomarkers were not lower than in the rest of Flanders. BioMed Central 2008-06-03 /pmc/articles/PMC2442593/ /pubmed/18522717 http://dx.doi.org/10.1186/1476-069X-7-26 Text en Copyright © 2008 De Coster et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
De Coster, Sam
Koppen, Gudrun
Bracke, Marc
Schroijen, Carmen
Den Hond, Elly
Nelen, Vera
Van de Mieroop, Els
Bruckers, Liesbeth
Bilau, Maaike
Baeyens, Willy
Schoeters, Greet
van Larebeke, Nik
Pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study
title Pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study
title_full Pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study
title_fullStr Pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study
title_full_unstemmed Pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study
title_short Pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study
title_sort pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442593/
https://www.ncbi.nlm.nih.gov/pubmed/18522717
http://dx.doi.org/10.1186/1476-069X-7-26
work_keys_str_mv AT decostersam pollutanteffectsongenotoxicparametersandtumorassociatedproteinlevelsinadultsacrosssectionalstudy
AT koppengudrun pollutanteffectsongenotoxicparametersandtumorassociatedproteinlevelsinadultsacrosssectionalstudy
AT brackemarc pollutanteffectsongenotoxicparametersandtumorassociatedproteinlevelsinadultsacrosssectionalstudy
AT schroijencarmen pollutanteffectsongenotoxicparametersandtumorassociatedproteinlevelsinadultsacrosssectionalstudy
AT denhondelly pollutanteffectsongenotoxicparametersandtumorassociatedproteinlevelsinadultsacrosssectionalstudy
AT nelenvera pollutanteffectsongenotoxicparametersandtumorassociatedproteinlevelsinadultsacrosssectionalstudy
AT vandemieroopels pollutanteffectsongenotoxicparametersandtumorassociatedproteinlevelsinadultsacrosssectionalstudy
AT bruckersliesbeth pollutanteffectsongenotoxicparametersandtumorassociatedproteinlevelsinadultsacrosssectionalstudy
AT bilaumaaike pollutanteffectsongenotoxicparametersandtumorassociatedproteinlevelsinadultsacrosssectionalstudy
AT baeyenswilly pollutanteffectsongenotoxicparametersandtumorassociatedproteinlevelsinadultsacrosssectionalstudy
AT schoetersgreet pollutanteffectsongenotoxicparametersandtumorassociatedproteinlevelsinadultsacrosssectionalstudy
AT vanlarebekenik pollutanteffectsongenotoxicparametersandtumorassociatedproteinlevelsinadultsacrosssectionalstudy