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Histone modifications and chromatin dynamics: a focus on filamentous fungi
The readout of the genetic information of eukaryotic organisms is significantly regulated by modifications of DNA and chromatin proteins. Chromatin alterations induce genome-wide and local changes in gene expression and affect a variety of processes in response to internal and external signals durin...
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Formato: | Texto |
Lenguaje: | English |
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Blackwell Publishing Ltd
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442719/ https://www.ncbi.nlm.nih.gov/pubmed/18221488 http://dx.doi.org/10.1111/j.1574-6976.2007.00100.x |
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author | Brosch, Gerald Loidl, Peter Graessle, Stefan |
author_facet | Brosch, Gerald Loidl, Peter Graessle, Stefan |
author_sort | Brosch, Gerald |
collection | PubMed |
description | The readout of the genetic information of eukaryotic organisms is significantly regulated by modifications of DNA and chromatin proteins. Chromatin alterations induce genome-wide and local changes in gene expression and affect a variety of processes in response to internal and external signals during growth, differentiation, development, in metabolic processes, diseases, and abiotic and biotic stresses. This review aims at summarizing the roles of histone H1 and the acetylation and methylation of histones in filamentous fungi and links this knowledge to the huge body of data from other systems. Filamentous fungi show a wide range of morphologies and have developed a complex network of genes that enables them to use a great variety of substrates. This fact, together with the possibility of simple and quick genetic manipulation, highlights these organisms as model systems for the investigation of gene regulation. However, little is still known about regulation at the chromatin level in filamentous fungi. Understanding the role of chromatin in transcriptional regulation would be of utmost importance with respect to the impact of filamentous fungi in human diseases and agriculture. The synthesis of compounds (antibiotics, immunosuppressants, toxins, and compounds with adverse effects) is also likely to be regulated at the chromatin level. |
format | Text |
id | pubmed-2442719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-24427192008-07-25 Histone modifications and chromatin dynamics: a focus on filamentous fungi Brosch, Gerald Loidl, Peter Graessle, Stefan FEMS Microbiol Rev Review Articles The readout of the genetic information of eukaryotic organisms is significantly regulated by modifications of DNA and chromatin proteins. Chromatin alterations induce genome-wide and local changes in gene expression and affect a variety of processes in response to internal and external signals during growth, differentiation, development, in metabolic processes, diseases, and abiotic and biotic stresses. This review aims at summarizing the roles of histone H1 and the acetylation and methylation of histones in filamentous fungi and links this knowledge to the huge body of data from other systems. Filamentous fungi show a wide range of morphologies and have developed a complex network of genes that enables them to use a great variety of substrates. This fact, together with the possibility of simple and quick genetic manipulation, highlights these organisms as model systems for the investigation of gene regulation. However, little is still known about regulation at the chromatin level in filamentous fungi. Understanding the role of chromatin in transcriptional regulation would be of utmost importance with respect to the impact of filamentous fungi in human diseases and agriculture. The synthesis of compounds (antibiotics, immunosuppressants, toxins, and compounds with adverse effects) is also likely to be regulated at the chromatin level. Blackwell Publishing Ltd 2008-05 2008-01-25 /pmc/articles/PMC2442719/ /pubmed/18221488 http://dx.doi.org/10.1111/j.1574-6976.2007.00100.x Text en © 2008 The Authors; Journal compilation © 2008 Federation of European Microbiological Societies Published by Blackwell Publishing Ltd |
spellingShingle | Review Articles Brosch, Gerald Loidl, Peter Graessle, Stefan Histone modifications and chromatin dynamics: a focus on filamentous fungi |
title | Histone modifications and chromatin dynamics: a focus on filamentous fungi |
title_full | Histone modifications and chromatin dynamics: a focus on filamentous fungi |
title_fullStr | Histone modifications and chromatin dynamics: a focus on filamentous fungi |
title_full_unstemmed | Histone modifications and chromatin dynamics: a focus on filamentous fungi |
title_short | Histone modifications and chromatin dynamics: a focus on filamentous fungi |
title_sort | histone modifications and chromatin dynamics: a focus on filamentous fungi |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442719/ https://www.ncbi.nlm.nih.gov/pubmed/18221488 http://dx.doi.org/10.1111/j.1574-6976.2007.00100.x |
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