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Histone modifications and chromatin dynamics: a focus on filamentous fungi

The readout of the genetic information of eukaryotic organisms is significantly regulated by modifications of DNA and chromatin proteins. Chromatin alterations induce genome-wide and local changes in gene expression and affect a variety of processes in response to internal and external signals durin...

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Detalles Bibliográficos
Autores principales: Brosch, Gerald, Loidl, Peter, Graessle, Stefan
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442719/
https://www.ncbi.nlm.nih.gov/pubmed/18221488
http://dx.doi.org/10.1111/j.1574-6976.2007.00100.x
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author Brosch, Gerald
Loidl, Peter
Graessle, Stefan
author_facet Brosch, Gerald
Loidl, Peter
Graessle, Stefan
author_sort Brosch, Gerald
collection PubMed
description The readout of the genetic information of eukaryotic organisms is significantly regulated by modifications of DNA and chromatin proteins. Chromatin alterations induce genome-wide and local changes in gene expression and affect a variety of processes in response to internal and external signals during growth, differentiation, development, in metabolic processes, diseases, and abiotic and biotic stresses. This review aims at summarizing the roles of histone H1 and the acetylation and methylation of histones in filamentous fungi and links this knowledge to the huge body of data from other systems. Filamentous fungi show a wide range of morphologies and have developed a complex network of genes that enables them to use a great variety of substrates. This fact, together with the possibility of simple and quick genetic manipulation, highlights these organisms as model systems for the investigation of gene regulation. However, little is still known about regulation at the chromatin level in filamentous fungi. Understanding the role of chromatin in transcriptional regulation would be of utmost importance with respect to the impact of filamentous fungi in human diseases and agriculture. The synthesis of compounds (antibiotics, immunosuppressants, toxins, and compounds with adverse effects) is also likely to be regulated at the chromatin level.
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spelling pubmed-24427192008-07-25 Histone modifications and chromatin dynamics: a focus on filamentous fungi Brosch, Gerald Loidl, Peter Graessle, Stefan FEMS Microbiol Rev Review Articles The readout of the genetic information of eukaryotic organisms is significantly regulated by modifications of DNA and chromatin proteins. Chromatin alterations induce genome-wide and local changes in gene expression and affect a variety of processes in response to internal and external signals during growth, differentiation, development, in metabolic processes, diseases, and abiotic and biotic stresses. This review aims at summarizing the roles of histone H1 and the acetylation and methylation of histones in filamentous fungi and links this knowledge to the huge body of data from other systems. Filamentous fungi show a wide range of morphologies and have developed a complex network of genes that enables them to use a great variety of substrates. This fact, together with the possibility of simple and quick genetic manipulation, highlights these organisms as model systems for the investigation of gene regulation. However, little is still known about regulation at the chromatin level in filamentous fungi. Understanding the role of chromatin in transcriptional regulation would be of utmost importance with respect to the impact of filamentous fungi in human diseases and agriculture. The synthesis of compounds (antibiotics, immunosuppressants, toxins, and compounds with adverse effects) is also likely to be regulated at the chromatin level. Blackwell Publishing Ltd 2008-05 2008-01-25 /pmc/articles/PMC2442719/ /pubmed/18221488 http://dx.doi.org/10.1111/j.1574-6976.2007.00100.x Text en © 2008 The Authors; Journal compilation © 2008 Federation of European Microbiological Societies Published by Blackwell Publishing Ltd
spellingShingle Review Articles
Brosch, Gerald
Loidl, Peter
Graessle, Stefan
Histone modifications and chromatin dynamics: a focus on filamentous fungi
title Histone modifications and chromatin dynamics: a focus on filamentous fungi
title_full Histone modifications and chromatin dynamics: a focus on filamentous fungi
title_fullStr Histone modifications and chromatin dynamics: a focus on filamentous fungi
title_full_unstemmed Histone modifications and chromatin dynamics: a focus on filamentous fungi
title_short Histone modifications and chromatin dynamics: a focus on filamentous fungi
title_sort histone modifications and chromatin dynamics: a focus on filamentous fungi
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442719/
https://www.ncbi.nlm.nih.gov/pubmed/18221488
http://dx.doi.org/10.1111/j.1574-6976.2007.00100.x
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