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Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting

BACKGROUND: A recurrent somatic mutation, E17K, in the pleckstrin homology domain of the AKT1 gene, has been recently described in breast, colorectal, and ovarian cancers. AKT1 is a pivotal mediator of signalling pathways involved in cell survival, proliferation and growth. The E17K mutation stimula...

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Detalles Bibliográficos
Autores principales:	Do, Hongdo, Solomon, Benjamin, Mitchell, Paul L, Fox, Stephen B, Dobrovic, Alexander
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442881/ https://www.ncbi.nlm.nih.gov/pubmed/18611285 http://dx.doi.org/10.1186/1756-0500-1-14

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