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Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

Mammalian cells respond to DNA double-strand breaks (DSBs) by recruiting DNA repair and cell-cycle checkpoint proteins to such sites. Central to these DNA damage response (DDR) events is the DNA damage mediator protein MDC1. MDC1 interacts with several DDR proteins, including the MRE11–RAD50–NBS1 (M...

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Detalles Bibliográficos
Autores principales:	Chapman, J Ross, Jackson, Stephen P
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2008
Materias:	Scientific Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442910/ https://www.ncbi.nlm.nih.gov/pubmed/18583988 http://dx.doi.org/10.1038/embor.2008.103

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