Hepatocellular Carcinoma and Sex Hormones

The liver is morphologically and functionally modulated by sex hormones. Long-term use of oral contraceptives and androgenic steroids can induce benign and malignant hepatocellular tumors. Hepatocellular carcinoma (HCC) is more prevalent in men than in women. The role of sex hormones and their recep...

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Detalles Bibliográficos
Autores principales: Nagasue, Naofumi, Kohno, Hitoshi
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443009/
https://www.ncbi.nlm.nih.gov/pubmed/1334694
http://dx.doi.org/10.1155/1992/72761
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author Nagasue, Naofumi
Kohno, Hitoshi
author_facet Nagasue, Naofumi
Kohno, Hitoshi
author_sort Nagasue, Naofumi
collection PubMed
description The liver is morphologically and functionally modulated by sex hormones. Long-term use of oral contraceptives and androgenic steroids can induce benign and malignant hepatocellular tumors. Hepatocellular carcinoma (HCC) is more prevalent in men than in women. The role of sex hormones and their receptors in the development of HCC was reviewed. Some HCCs may be androgen dependent but others may be estrogen or even both dependent. Further studies are mandatory in order to utilize such characteristics of HCC for an effective prophylaxis and therapy of this tumor.
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spelling pubmed-24430092008-07-08 Hepatocellular Carcinoma and Sex Hormones Nagasue, Naofumi Kohno, Hitoshi HPB Surg Research Article The liver is morphologically and functionally modulated by sex hormones. Long-term use of oral contraceptives and androgenic steroids can induce benign and malignant hepatocellular tumors. Hepatocellular carcinoma (HCC) is more prevalent in men than in women. The role of sex hormones and their receptors in the development of HCC was reviewed. Some HCCs may be androgen dependent but others may be estrogen or even both dependent. Further studies are mandatory in order to utilize such characteristics of HCC for an effective prophylaxis and therapy of this tumor. Hindawi Publishing Corporation 1992 /pmc/articles/PMC2443009/ /pubmed/1334694 http://dx.doi.org/10.1155/1992/72761 Text en Copyright © 1992 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nagasue, Naofumi
Kohno, Hitoshi
Hepatocellular Carcinoma and Sex Hormones
title Hepatocellular Carcinoma and Sex Hormones
title_full Hepatocellular Carcinoma and Sex Hormones
title_fullStr Hepatocellular Carcinoma and Sex Hormones
title_full_unstemmed Hepatocellular Carcinoma and Sex Hormones
title_short Hepatocellular Carcinoma and Sex Hormones
title_sort hepatocellular carcinoma and sex hormones
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443009/
https://www.ncbi.nlm.nih.gov/pubmed/1334694
http://dx.doi.org/10.1155/1992/72761
work_keys_str_mv AT nagasuenaofumi hepatocellularcarcinomaandsexhormones
AT kohnohitoshi hepatocellularcarcinomaandsexhormones

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