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Molecular evolution of B(6 )enzymes: Binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B(6 )protoenzyme

BACKGROUND: The pyridoxal-5'-phosphate (PLP)-dependent or vitamin B(6)-dependent enzymes that catalyze manifold reactions in the metabolism of amino acids belong to no fewer than four evolutionarily independent protein families. The multiple evolutionary origin and the essential mechanistic rol...

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Detalles Bibliográficos
Autores principales:	Vacca, Rosa A, Giannattasio, Sergio, Capitani, Guido, Marra, Ersilia, Christen, Philipp
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443152/ https://www.ncbi.nlm.nih.gov/pubmed/18565210 http://dx.doi.org/10.1186/1471-2091-9-17

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