Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report

INTRODUCTION: Whipple's disease is a rare systemic infectious disorder caused by Tropheryma whipplei. CASE PRESENTATION: We report a 68-year-old male with Whipple's disease of the central nervous system following long-term antibiotic therapy and many years after the initial clinical onset....

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Detalles Bibliográficos
Autores principales: Gundling, Felix, Wittenburg, Henning, Tannapfel, Andrea, Mossner, Joachim
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443157/
https://www.ncbi.nlm.nih.gov/pubmed/18522718
http://dx.doi.org/10.1186/1752-1947-2-191
Descripción
Sumario:INTRODUCTION: Whipple's disease is a rare systemic infectious disorder caused by Tropheryma whipplei. CASE PRESENTATION: We report a 68-year-old male with Whipple's disease of the central nervous system following long-term antibiotic therapy and many years after the initial clinical onset. CONCLUSION: The combination of trimethoprim and sulphamethoxazole does not prevent or cure involvement of the central nervous system in all patients with Whipple's disease. If relapse of the central nervous system occurs treatment with meropenem might be a useful alternative.

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