Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report

INTRODUCTION: Whipple's disease is a rare systemic infectious disorder caused by Tropheryma whipplei. CASE PRESENTATION: We report a 68-year-old male with Whipple's disease of the central nervous system following long-term antibiotic therapy and many years after the initial clinical onset....

Descripción completa

Detalles Bibliográficos
Autores principales: Gundling, Felix, Wittenburg, Henning, Tannapfel, Andrea, Mossner, Joachim
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443157/
https://www.ncbi.nlm.nih.gov/pubmed/18522718
http://dx.doi.org/10.1186/1752-1947-2-191
_version_ 1782156804683202560
author Gundling, Felix
Wittenburg, Henning
Tannapfel, Andrea
Mossner, Joachim
author_facet Gundling, Felix
Wittenburg, Henning
Tannapfel, Andrea
Mossner, Joachim
author_sort Gundling, Felix
collection PubMed
description INTRODUCTION: Whipple's disease is a rare systemic infectious disorder caused by Tropheryma whipplei. CASE PRESENTATION: We report a 68-year-old male with Whipple's disease of the central nervous system following long-term antibiotic therapy and many years after the initial clinical onset. CONCLUSION: The combination of trimethoprim and sulphamethoxazole does not prevent or cure involvement of the central nervous system in all patients with Whipple's disease. If relapse of the central nervous system occurs treatment with meropenem might be a useful alternative.
format Text
id pubmed-2443157
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-24431572008-07-04 Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report Gundling, Felix Wittenburg, Henning Tannapfel, Andrea Mossner, Joachim J Med Case Reports Case Report INTRODUCTION: Whipple's disease is a rare systemic infectious disorder caused by Tropheryma whipplei. CASE PRESENTATION: We report a 68-year-old male with Whipple's disease of the central nervous system following long-term antibiotic therapy and many years after the initial clinical onset. CONCLUSION: The combination of trimethoprim and sulphamethoxazole does not prevent or cure involvement of the central nervous system in all patients with Whipple's disease. If relapse of the central nervous system occurs treatment with meropenem might be a useful alternative. BioMed Central 2008-06-03 /pmc/articles/PMC2443157/ /pubmed/18522718 http://dx.doi.org/10.1186/1752-1947-2-191 Text en Copyright © 2008 Gundling et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Gundling, Felix
Wittenburg, Henning
Tannapfel, Andrea
Mossner, Joachim
Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report
title Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report
title_full Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report
title_fullStr Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report
title_full_unstemmed Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report
title_short Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report
title_sort neurological presentation of whipple's disease after long-term antibiotic treatment: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443157/
https://www.ncbi.nlm.nih.gov/pubmed/18522718
http://dx.doi.org/10.1186/1752-1947-2-191
work_keys_str_mv AT gundlingfelix neurologicalpresentationofwhipplesdiseaseafterlongtermantibiotictreatmentacasereport
AT wittenburghenning neurologicalpresentationofwhipplesdiseaseafterlongtermantibiotictreatmentacasereport
AT tannapfelandrea neurologicalpresentationofwhipplesdiseaseafterlongtermantibiotictreatmentacasereport
AT mossnerjoachim neurologicalpresentationofwhipplesdiseaseafterlongtermantibiotictreatmentacasereport

Ejemplares similares