Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole

A class of Ag(I) N-heterocyclic carbene silver complexes, 1–3, derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes 1–3 are active against the ovarian and b...

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Detalles Bibliográficos
Autores principales: Medvetz, Doug A., Hindi, Khadijah M., Panzner, Matthew J., Ditto, Andrew J., Yun, Yang H., Youngs, Wiley J.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443426/
https://www.ncbi.nlm.nih.gov/pubmed/18615197
http://dx.doi.org/10.1155/2008/384010
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author Medvetz, Doug A.
Hindi, Khadijah M.
Panzner, Matthew J.
Ditto, Andrew J.
Yun, Yang H.
Youngs, Wiley J.
author_facet Medvetz, Doug A.
Hindi, Khadijah M.
Panzner, Matthew J.
Ditto, Andrew J.
Yun, Yang H.
Youngs, Wiley J.
author_sort Medvetz, Doug A.
collection PubMed
description A class of Ag(I) N-heterocyclic carbene silver complexes, 1–3, derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes 1–3 are active against the ovarian and breast cancer cell lines. A preliminary in vivo study shows 1 to be active against ovarian cancer in mice. The results obtained in these studies warrant further investigation of these compounds in vivo.
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spelling pubmed-24434262008-07-09 Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole Medvetz, Doug A. Hindi, Khadijah M. Panzner, Matthew J. Ditto, Andrew J. Yun, Yang H. Youngs, Wiley J. Met Based Drugs Research Article A class of Ag(I) N-heterocyclic carbene silver complexes, 1–3, derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes 1–3 are active against the ovarian and breast cancer cell lines. A preliminary in vivo study shows 1 to be active against ovarian cancer in mice. The results obtained in these studies warrant further investigation of these compounds in vivo. Hindawi Publishing Corporation 2008 2008-07-03 /pmc/articles/PMC2443426/ /pubmed/18615197 http://dx.doi.org/10.1155/2008/384010 Text en Copyright © 2008 Doug A. Medvetz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Medvetz, Doug A.
Hindi, Khadijah M.
Panzner, Matthew J.
Ditto, Andrew J.
Yun, Yang H.
Youngs, Wiley J.
Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole
title Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole
title_full Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole
title_fullStr Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole
title_full_unstemmed Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole
title_short Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole
title_sort anticancer activity of ag(i) n-heterocyclic carbene complexes derived from 4,5-dichloro-1h-imidazole
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443426/
https://www.ncbi.nlm.nih.gov/pubmed/18615197
http://dx.doi.org/10.1155/2008/384010
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