Cargando…

Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD

BACKGROUND: Attention-Deficit/Hyperactivity Disorder (ADHD) is a heterogeneous disorder from both clinical and pathogenic viewpoints. Executive function deficits are considered among the most important pathogenic pathways leading to ADHD and may index part of the heterogeneity in this disorder. METH...

Descripción completa

Detalles Bibliográficos
Autores principales: Karama, Sherif, Grizenko, Natalie, Sonuga-Barke, Edmund, Doyle, Alysa, Biederman, Joseph, Mbekou, Valentin, Polotskaia, Anna, Ter-Stepanian, Marina, De Guzman, Rosherrie, Bellingham, Johanne, Sengupta, Sarojini, Joober, Ridha
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443797/
https://www.ncbi.nlm.nih.gov/pubmed/18559107
http://dx.doi.org/10.1186/1471-244X-8-45
_version_ 1782156848006168576
author Karama, Sherif
Grizenko, Natalie
Sonuga-Barke, Edmund
Doyle, Alysa
Biederman, Joseph
Mbekou, Valentin
Polotskaia, Anna
Ter-Stepanian, Marina
De Guzman, Rosherrie
Bellingham, Johanne
Sengupta, Sarojini
Joober, Ridha
author_facet Karama, Sherif
Grizenko, Natalie
Sonuga-Barke, Edmund
Doyle, Alysa
Biederman, Joseph
Mbekou, Valentin
Polotskaia, Anna
Ter-Stepanian, Marina
De Guzman, Rosherrie
Bellingham, Johanne
Sengupta, Sarojini
Joober, Ridha
author_sort Karama, Sherif
collection PubMed
description BACKGROUND: Attention-Deficit/Hyperactivity Disorder (ADHD) is a heterogeneous disorder from both clinical and pathogenic viewpoints. Executive function deficits are considered among the most important pathogenic pathways leading to ADHD and may index part of the heterogeneity in this disorder. METHODS: To investigate the relationship between the dopamine transporter gene (SLC6A3) 3'-UTR VNTR genotypes and executive function in children with ADHD, 196 children diagnosed with ADHD were sequentially recruited, genotyped, and tested using a battery of three neuropsychological tests aimed at assessing the different aspects of executive functioning. RESULTS: Taking into account a correction for multiple comparisons, the main finding of this study is a significant genotype effect on performances on the Tower of London (F = 6.902, p = 0.009) and on the Wechsler Intelligence Scale for Children, Third Edition (WISC-III) Freedom From Distractibility Index (F = 7.125, p = 0.008), as well as strong trends on Self Ordered Pointing Task error scores (F = 4,996 p = 0.026) and WISC-III Digit Span performance (F = 6.28, p = 0.023). Children with the 9/10 genotype exhibited, on average, a poorer performance on all four measures compared to children with the 10/10 genotype. No effect of genotype on Wisconsin Card Sorting Test measures of performance was detected. CONCLUSION: Results are compatible with the view that SLC6A3 genotype may modulate components of executive function performance in children with ADHD.
format Text
id pubmed-2443797
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-24437972008-07-08 Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD Karama, Sherif Grizenko, Natalie Sonuga-Barke, Edmund Doyle, Alysa Biederman, Joseph Mbekou, Valentin Polotskaia, Anna Ter-Stepanian, Marina De Guzman, Rosherrie Bellingham, Johanne Sengupta, Sarojini Joober, Ridha BMC Psychiatry Research Article BACKGROUND: Attention-Deficit/Hyperactivity Disorder (ADHD) is a heterogeneous disorder from both clinical and pathogenic viewpoints. Executive function deficits are considered among the most important pathogenic pathways leading to ADHD and may index part of the heterogeneity in this disorder. METHODS: To investigate the relationship between the dopamine transporter gene (SLC6A3) 3'-UTR VNTR genotypes and executive function in children with ADHD, 196 children diagnosed with ADHD were sequentially recruited, genotyped, and tested using a battery of three neuropsychological tests aimed at assessing the different aspects of executive functioning. RESULTS: Taking into account a correction for multiple comparisons, the main finding of this study is a significant genotype effect on performances on the Tower of London (F = 6.902, p = 0.009) and on the Wechsler Intelligence Scale for Children, Third Edition (WISC-III) Freedom From Distractibility Index (F = 7.125, p = 0.008), as well as strong trends on Self Ordered Pointing Task error scores (F = 4,996 p = 0.026) and WISC-III Digit Span performance (F = 6.28, p = 0.023). Children with the 9/10 genotype exhibited, on average, a poorer performance on all four measures compared to children with the 10/10 genotype. No effect of genotype on Wisconsin Card Sorting Test measures of performance was detected. CONCLUSION: Results are compatible with the view that SLC6A3 genotype may modulate components of executive function performance in children with ADHD. BioMed Central 2008-06-17 /pmc/articles/PMC2443797/ /pubmed/18559107 http://dx.doi.org/10.1186/1471-244X-8-45 Text en Copyright © 2008 Karama et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Karama, Sherif
Grizenko, Natalie
Sonuga-Barke, Edmund
Doyle, Alysa
Biederman, Joseph
Mbekou, Valentin
Polotskaia, Anna
Ter-Stepanian, Marina
De Guzman, Rosherrie
Bellingham, Johanne
Sengupta, Sarojini
Joober, Ridha
Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD
title Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD
title_full Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD
title_fullStr Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD
title_full_unstemmed Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD
title_short Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD
title_sort dopamine transporter 3'utr vntr genotype is a marker of performance on executive function tasks in children with adhd
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443797/
https://www.ncbi.nlm.nih.gov/pubmed/18559107
http://dx.doi.org/10.1186/1471-244X-8-45
work_keys_str_mv AT karamasherif dopaminetransporter3utrvntrgenotypeisamarkerofperformanceonexecutivefunctiontasksinchildrenwithadhd
AT grizenkonatalie dopaminetransporter3utrvntrgenotypeisamarkerofperformanceonexecutivefunctiontasksinchildrenwithadhd
AT sonugabarkeedmund dopaminetransporter3utrvntrgenotypeisamarkerofperformanceonexecutivefunctiontasksinchildrenwithadhd
AT doylealysa dopaminetransporter3utrvntrgenotypeisamarkerofperformanceonexecutivefunctiontasksinchildrenwithadhd
AT biedermanjoseph dopaminetransporter3utrvntrgenotypeisamarkerofperformanceonexecutivefunctiontasksinchildrenwithadhd
AT mbekouvalentin dopaminetransporter3utrvntrgenotypeisamarkerofperformanceonexecutivefunctiontasksinchildrenwithadhd
AT polotskaiaanna dopaminetransporter3utrvntrgenotypeisamarkerofperformanceonexecutivefunctiontasksinchildrenwithadhd
AT terstepanianmarina dopaminetransporter3utrvntrgenotypeisamarkerofperformanceonexecutivefunctiontasksinchildrenwithadhd
AT deguzmanrosherrie dopaminetransporter3utrvntrgenotypeisamarkerofperformanceonexecutivefunctiontasksinchildrenwithadhd
AT bellinghamjohanne dopaminetransporter3utrvntrgenotypeisamarkerofperformanceonexecutivefunctiontasksinchildrenwithadhd
AT senguptasarojini dopaminetransporter3utrvntrgenotypeisamarkerofperformanceonexecutivefunctiontasksinchildrenwithadhd
AT jooberridha dopaminetransporter3utrvntrgenotypeisamarkerofperformanceonexecutivefunctiontasksinchildrenwithadhd