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Prelimbic and Infralimbic Prefrontal Cortex Interact during Fast Network Oscillations

BACKGROUND: The medial prefrontal cortex has been implicated in a variety of cognitive and executive processes such as decision making and working memory. The medial prefrontal cortex of rodents consists of several areas including the prelimbic and infralimbic cortex that are thought to be involved...

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Autores principales: van Aerde, Karlijn I., Heistek, Tim S., Mansvelder, Huibert D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2444037/
https://www.ncbi.nlm.nih.gov/pubmed/18628964
http://dx.doi.org/10.1371/journal.pone.0002725
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author van Aerde, Karlijn I.
Heistek, Tim S.
Mansvelder, Huibert D.
author_facet van Aerde, Karlijn I.
Heistek, Tim S.
Mansvelder, Huibert D.
author_sort van Aerde, Karlijn I.
collection PubMed
description BACKGROUND: The medial prefrontal cortex has been implicated in a variety of cognitive and executive processes such as decision making and working memory. The medial prefrontal cortex of rodents consists of several areas including the prelimbic and infralimbic cortex that are thought to be involved in different aspects of cognitive performance. Despite the distinct roles in cognitive behavior that have been attributed to prelimbic and infralimbic cortex, little is known about neuronal network functioning of these areas, and whether these networks show any interaction during fast network oscillations. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that fast network oscillations in rat infralimbic cortex slices occur at higher frequencies and with higher power than oscillations in prelimbic cortex. The difference in oscillation frequency disappeared when prelimbic and infralimbic cortex were disconnected. CONCLUSIONS/SIGNIFICANCE: Our data indicate that neuronal networks of prelimbic and infralimbic cortex can sustain fast network oscillations independent of each other, but suggest that neuronal networks of prelimbic and infralimbic cortex are interacting during these oscillations.
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spelling pubmed-24440372008-07-16 Prelimbic and Infralimbic Prefrontal Cortex Interact during Fast Network Oscillations van Aerde, Karlijn I. Heistek, Tim S. Mansvelder, Huibert D. PLoS One Research Article BACKGROUND: The medial prefrontal cortex has been implicated in a variety of cognitive and executive processes such as decision making and working memory. The medial prefrontal cortex of rodents consists of several areas including the prelimbic and infralimbic cortex that are thought to be involved in different aspects of cognitive performance. Despite the distinct roles in cognitive behavior that have been attributed to prelimbic and infralimbic cortex, little is known about neuronal network functioning of these areas, and whether these networks show any interaction during fast network oscillations. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that fast network oscillations in rat infralimbic cortex slices occur at higher frequencies and with higher power than oscillations in prelimbic cortex. The difference in oscillation frequency disappeared when prelimbic and infralimbic cortex were disconnected. CONCLUSIONS/SIGNIFICANCE: Our data indicate that neuronal networks of prelimbic and infralimbic cortex can sustain fast network oscillations independent of each other, but suggest that neuronal networks of prelimbic and infralimbic cortex are interacting during these oscillations. Public Library of Science 2008-07-16 /pmc/articles/PMC2444037/ /pubmed/18628964 http://dx.doi.org/10.1371/journal.pone.0002725 Text en van Aerde et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
van Aerde, Karlijn I.
Heistek, Tim S.
Mansvelder, Huibert D.
Prelimbic and Infralimbic Prefrontal Cortex Interact during Fast Network Oscillations
title Prelimbic and Infralimbic Prefrontal Cortex Interact during Fast Network Oscillations
title_full Prelimbic and Infralimbic Prefrontal Cortex Interact during Fast Network Oscillations
title_fullStr Prelimbic and Infralimbic Prefrontal Cortex Interact during Fast Network Oscillations
title_full_unstemmed Prelimbic and Infralimbic Prefrontal Cortex Interact during Fast Network Oscillations
title_short Prelimbic and Infralimbic Prefrontal Cortex Interact during Fast Network Oscillations
title_sort prelimbic and infralimbic prefrontal cortex interact during fast network oscillations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2444037/
https://www.ncbi.nlm.nih.gov/pubmed/18628964
http://dx.doi.org/10.1371/journal.pone.0002725
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