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AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand
BACKGROUND: The regulation of Notch signaling heavily relies on ubiquitination events. Drosophila Su(dx), a member of the HECT family of ubiquitin-ligases, has been described as a negative regulator of Notch signaling, acting on the post-endocytic sorting of Notch. The mammalian ortholog of Su(dx),...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2444042/ https://www.ncbi.nlm.nih.gov/pubmed/18628966 http://dx.doi.org/10.1371/journal.pone.0002735 |